MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A)
1_MAAIR 6_ MGKLT 11_ TMPAG 16_ LIYAS 21_ VSVHA 26_ AKQEE 31_ SKKQL 36_ VKPEQ 41_ LPIYT 46_ APPLQ 51_ SKYVE 56_ EQPGH 61_ LQMGF 66_ ASIRT 71_ ATGCY 76_ IGWCK 81_ GVYVF 86_ VKNGI 91_ MDTVQ 96_ FGKDA 101_ YVYLK 106_ NPPRD 111_ FLPKM 116_ GVITV 121_ SGLAG 126_ LVSAR 131_ KGSKF 136_ KKITY 141_ PLGLA 146_ TLGAT 151_ VCYPV 156_ QSVII 161_ AKVTA 166_ KKVYA 171_ TSQQI 176_ FGAVK 181_ SLWTK 186_ SSKEE 191_ SLPKP 196_ KEKTK 201_ LGSSS 206_ EIEVP 211_ AKTTH 216_ VLKHS 221_ VPLPT 226_ ELSSE 231_ AKTKS 236_ ESTSG 241_ ATQFM 246_ PDPKL 251_ MDHGQ 256_ SHPED 261_IDMYS
1: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979)