R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
1_MQFRL 6_ FSFAL 11_ IILNC 16_ MDYSH 21_ CQGNR 26_ WRRSK 31_ RASYV 36_ SNPIC 41_ KGCLS 46_ CSKDN 51_ GCSRC 56_ QQKLF 61_ FFLRR 66_ EGMRQ 71_ YGECL 76_ HSCPS 81_ GYYGH 86_ RAPDM 91_ NRCAR 96_ CRIEN 101_ CDSCF 106_ SKDFC 111_ TKCKV 116_ GFYLH 121_ RGRCF 126_ DECPD 131_ GFAPL 136_ EETME 141_ CVEGC 146_ EVGHW 151_ SEWGT 156_ CSRNN 161_ RTCGF 166_ KWGLE 171_ TRTRQ 176_ IVKKP 181_ VKDTI 186_ LCPTI 191_ AESRR 196_ CKMTM 201_ RHCPG 206_ GKRTP 211_ KAKEK 216_ RNKKK 221_ KRKLI 226_ ERAQE 231_ QHSVF 236_LATDR
1: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720)