Cytochrome P450 26C1 (EC 1.14.-.-)
1_MFPWG 6_ LSCLS 11_ VLGAA 16_ GTALL 21_ CAGLL 26_ LSLAQ 31_ HLWTL 36_ RWMLS 41_ RDRAS 46_ TLPLP 51_ KGSMG 56_ WPFFG 61_ ETLHW 66_ LVQGS 71_ RFHSS 76_ RRERY 81_ GTVFK 86_ THLLG 91_ RPVIR 96_ VSGAE 101_ NVRTI 106_ LLGEH 111_ RLVRS 116_ QWPQS 121_ AHILL 126_ GSHTL 131_ LGAVG 136_ EPHRR 141_ RRKVL 146_ ARVFS 151_ RAALE 156_ RYVPR 161_ LQGAL 166_ RHEVR 171_ SWCAA 176_ GGPVS 181_ VYDAS 186_ KALTF 191_ RMAAR 196_ ILLGL 201_ RLDEA 206_ QCATL 211_ ARTFE 216_ QLVEN 221_ LFSLP 226_ LDVPF 231_ SGLRK 236_ GIRAR 241_ DQLHR 246_ HLEGA 251_ ISEKL 256_ HEDKA 261_ AEPGD 266_ ALDLI 271_ IHSAR 276_ ELGHE 281_ PSMQE 286_ LKESA 291_ VELLF 296_ AAFFT 301_ TASAS 306_ TSLVL 311_ LLLQH 316_ PAAIA 321_ KIREE 326_ LVAQG 331_ LGRAC 336_ GCAPG 341_ AAGGS 346_ EGPPP 351_ DCGCE 356_ PDLSL 361_ AALGR 366_ LRYVD 371_ CVVKE 376_ VLRLL 381_ PPVSG 386_ GYRTA 391_ LRTFE 396_ LDGYQ 401_ IPKGW 406_ SVMYS 411_ IRDTH 416_ ETAAV 421_ YRSPP 426_ EGFDP 431_ ERFGA 436_ AREDS 441_ RGASS 446_ RFHYI 451_ PFGGG 456_ ARSCL 461_ GQELA 466_ QAVLQ 471_ LLAVE 476_ LVRTA 481_ RWELA 486_ TPAFP 491_ AMQTV 496_ PIVHP 501_ VDGLR 506_ LFFHP 511_ LTPSV 516_AGNGL
1: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:14532297). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 (PubMed:14532297). Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling (Probable). Able to metabolize other RAs such as 9-cis with high efficiency (PubMed:14532297). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole (PubMed:14532297). In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (By similarity)