Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8)
1_MWKRS 6_ EQMKI 11_ KSGKC 16_ NMAAA 21_ METEQ 26_ LGVEI 31_ FETAD 36_ CEENI 41_ ESQDR 46_ PKLEP 51_ FYVER 56_ YSWSQ 61_ LKKLL 66_ ADTRK 71_ YHGYM 76_ MAKAP 81_ HDFMF 86_ VKRND 91_ PDGPH 96_ SDRIY 101_ YLAMS 106_ GENRE 111_ NTLFY 116_ SEIPK 121_ TINRA 126_ AVLML 131_ SWKPL 136_ LDLFQ 141_ ATLDY 146_ GMYSR 151_ EEELL 156_ RERKR 161_ IGTVG 166_ IASYD 171_ YHQGS 176_ GTFLF 181_ QAGSG 186_ IYHVK 191_ DGGPQ 196_ GFTQQ 201_ PLRPN 206_ LVETS 211_ CPNIR 216_ MDPKL 221_ CPADP 226_ DWIAF 231_ IHSND 236_ IWISN 241_ IVTRE 246_ ERRLT 251_ YVHNE 256_ LANME 261_ EDARS 266_ AGVAT 271_ FVLQE 276_ EFDRY 281_ SGYWW 286_ CPKAE 291_ TTPSG 296_ GKILR 301_ ILYEE 306_ NDESE 311_ VEIIH 316_ VTSPM 321_ LETRR 326_ ADSFR 331_ YPKTG 336_ TANPK 341_ VTFKM 346_ SEIMI 351_ DAEGR 356_ IIDVI 361_ DKELI 366_ QPFEI 371_ LFEGV 376_ EYIAR 381_ AGWTP 386_ EGKYA 391_ WSILL 396_ DRSQT 401_ RLQIV 406_ LISPE 411_ LFIPV 416_ EDDVM 421_ ERQRL 426_ IESVP 431_ DSVTP 436_ LIIYE 441_ ETTDI 446_ WINIH 451_ DIFHV 456_ FPQSH 461_ EEEIE 466_ FIFAS 471_ ECKTG 476_ FRHLY 481_ KITSI 486_ LKESK 491_ YKRSS 496_ GGLPA 501_ PSDFK 506_ CPIKE 511_ EIAIT 516_ SGEWE 521_ VLGRH 526_ GSNIQ 531_ VDEVR 536_ RLVYF 541_ EGTKD 546_ SPLEH 551_ HLYVV 556_ SYVNP 561_ GEVTR 566_ LTDRG 571_ YSHSC 576_ CISQH 581_ CDFFI 586_ SKYSN 591_ QKNPH 596_ CVSLY 601_ KLSSP 606_ EDDPT 611_ CKTKE 616_ FWATI 621_ LDSAG 626_ PLPDY 631_ TPPEI 636_ FSFES 641_ TTGFT 646_ LYGML 651_ YKPHD 656_ LQPGK 661_ KYPTV 666_ LFIYG 671_ GPQVQ 676_ LVNNR 681_ FKGVK 686_ YFRLN 691_ TLASL 696_ GYVVV 701_ VIDNR 706_ GSCHR 711_ GLKFE 716_ GAFKY 721_ KMGQI 726_ EIDDQ 731_ VEGLQ 736_ YLASR 741_ YDFID 746_ LDRVG 751_ IHGWS 756_ YGGYL 761_ SLMAL 766_ MQRSD 771_ IFRVA 776_ IAGAP 781_ VTLWI 786_ FYDTG 791_ YTERY 796_ MGHPD 801_ QNEQG 806_ YYLGS 811_ VAMQA 816_ EKFPS 821_ EPNRL 826_ LLLHG 831_ FLDEN 836_ VHFAH 841_ TSILL 846_ SFLVR 851_ AGKPY 856_ DLQIY 861_ PQERH 866_ SIRVP 871_ ESGEH 876_ YELHL 881_ LHYLQ 886_ ENLGS 891_RIAAL
1: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)