Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
1_MDEEN 6_ MTKSE 11_ EQQPL 16_ SLQKA 21_ LQQCE 26_ LVQNM 31_ IDLSI 36_ SNLEG 41_ LRTKC 46_ ATSND 51_ LTQKE 56_ IRTLE 61_ SKLVK 66_ YFSRQ 71_ LSCKK 76_ KVALQ 81_ ERNAE 86_ LDGFP 91_ QLRHW 96_ FRIVD 101_ VRKEV 106_ LEEIS 111_ PGQLS 116_ LEDLL 121_ EMTDE 126_ QVCET 131_ VEKYG 136_ ANREE 141_ CARLN 146_ ASLSC 151_ LRNVH 156_ MSGGN 161_ LSKQD 166_ WTIQW 171_ PTTET 176_ GKENN 181_ PVCPP 186_ EPTPW 191_ IRTHL 196_ SQSPR 201_ VPSKC 206_ VQHYC 211_ HTSPT 216_ PGAPV 221_ YTHVD 226_ RLTVD 231_ AYPGL 236_ CPPPP 241_ LESGH 246_ RSLPP 251_ SPRQR 256_ HAVRT 261_ PPRTP 266_ NIVTT 271_ VTPPG 276_ TPPMR 281_ KKNKL 286_ KPPGT 291_ PPPSS 296_ RKLIH 301_ LIPGF 306_ TALHR 311_ SKSHE 316_ FQLGH 321_ RVDEA 326_ HTPKA 331_ KKKSK 336_ PLNLK 341_ IHSSV 346_ GSCEN 351_ IPSQQ 356_ RSPLL 361_ SERSL 366_ RSFFV 371_ GHAPF 376_ LPSTP 381_ PVHTE 386_ ANFSA 391_ NTLSV 396_ PRWSP 401_ QIPRR 406_ DLGNS 411_ IKHRF 416_ STKYW 421_ MSQTC 426_ TVCGK 431_ GMLFG 436_ LKCKN 441_ CKLKC 446_ HNKCT 451_ KEAPP 456_ CHLLI 461_ IHRGD 466_ PARLV 471_ RTESV 476_ PCDIN 481_ NPLRK 486_ PPRYS 491_ DLHIS 496_ QTLPK 501_ TNKIN 506_ KDHIP 511_ VPYQP 516_ DSSSN 521_ PSSTT 526_ SSTPS 531_ SPAPP 536_ LPPSA 541_ TPPSP 546_ LHPSP 551_ QCTRQ 556_ QKNFN 561_ LPASH 566_ YYKYK 571_ QQFIF 576_ PDVVP 581_ VPETP 586_ TRAPQ 591_ VILHP 596_ VTSNP 601_ ILEGN 606_ PLLQI 611_ EVEPT 616_ SENEE 621_ VHDEA 626_ EESED 631_ DFEEM 636_ NLSLL 641_ SARSF 646_ PRKAS 651_ QTSIF 656_ LQEWD 661_ IPFEQ 666_ LEIGE 671_ LIGKG 676_ RFGQV 681_ YHGRW 686_ HGEVA 691_ IRLID 696_ IERDN 701_ EDQLK 706_ AFKRE 711_ VMAYR 716_ QTRHE 721_ NVVLF 726_ MGACM 731_ SPPHL 736_ AIITS 741_ LCKGR 746_ TLYSV 751_ VRDAK 756_ IVLDV 761_ NKTRQ 766_ IAQEI 771_ VKGMG 776_ YLHAK 781_ GILHK 786_ DLKSK 791_ NVFYD 796_ NGKVV 801_ ITDFG 806_ LFSIS 811_ GVLQA 816_ GRRED 821_ KLRIQ 826_ NGWLC 831_ HLAPE 836_ IIRQL 841_ SPDTE 846_ EDKLP 851_ FSKHS 856_ DVFAL 861_ GTIWY 866_ ELHAR 871_ EWPFK 876_ TQPAE 881_ AIIWQ 886_ MGTGM 891_ KPNLS 896_ QIGMG 901_ KEISD 906_ ILLFC 911_ WAFEQ 916_ EERPT 921_ FTKLM 926_ DMLEK 931_ LPKRN 936_ RRLSH 941_PGHFW
1: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production