Ran-binding protein 10 (RanBP10)
1_MAAAT 6_ ADPGA 11_ GNPQP 16_ GDSSG 21_ GGAGG 26_ GLPSP 31_ GEQEL 36_ SRRLQ 41_ RLYPA 46_ VNQQE 51_ TPLPR 56_ SWSPK 61_ DKYNY 66_ IGLSQ 71_ GNLRV 76_ HYKGH 81_ GKNHK 86_ DAASV 91_ RATHP 96_ IPAAC 101_ GIYYF 106_ EVKIV 111_ SKGRD 116_ GYMGI 121_ GLSAQ 126_ GVNMN 131_ RLPGW 136_ DKHSY 141_ GYHGD 146_ DGHSF 151_ CSSGT 156_ GQPYG 161_ PTFTT 166_ GDVIG 171_ CCVNL 176_ INGTC 181_ FYTKN 186_ GHSLG 191_ IAFTD 196_ LPANL 201_ YPTVG 206_ LQTPG 211_ EIVDA 216_ NFGQQ 221_ PFLFD 226_ IEDYM 231_ REWRA 236_ KVQGT 241_ VHCFP 246_ ISARL 251_ GEWQA 256_ VLQNM 261_ VSSYL 266_ VHHGY 271_ CATAT 276_ AFARM 281_ TETPI 286_ QEEQA 291_ SIKNR 296_ QKIQK 301_ LVLEG 306_ RVGEA 311_ IETTQ 316_ RFYPG 321_ LLEHN 326_ PNLLF 331_ MLKCR 336_ QFVEM 341_ VNGTD 346_ SEVRS 351_ LSSRS 356_ PKSQD 361_ SYPGS 366_ PSLSP 371_ RHGPS 376_ SSHMH 381_ NTGAD 386_ SPSCS 391_ NGVAS 396_ TKSKQ 401_ NHSKY 406_ PAPSS 411_ SSSSS 416_ SSSSS 421_ SSPSS 426_ VNYSE 431_ SNSTD 436_ STKSQ 441_ HHSST 446_ SNQET 451_ SDSEM 456_ EMEAE 461_ HYPNG 466_ VLGSM 471_ STRIV 476_ NGAYK 481_ HEDLQ 486_ TDESS 491_ MDDRH 496_ PRRQL 501_ CGGNQ 506_ AATER 511_ IILFG 516_ RELQA 521_ LSEQL 526_ GREYG 531_ KNLAH 536_ TEMLQ 541_ DAFSL 546_ LAYSD 551_ PWSCP 556_ VGQQL 561_ DPIQR 566_ EPVCA 571_ ALNSA 576_ ILESQ 581_ NLPKQ 586_ PPLML 591_ ALGQA 596_ SECLR 601_ LMARA 606_ GLGSC 611_SFARV
1: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity)