Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon)
1_MLVHT 6_ YSAME 11_ RPDGL 16_ GAAAG 21_ GARLS 26_ SLPQA 31_ AYGPA 36_ PPLCH 41_ TPAAT 46_ AAAEF 51_ QPPYF 56_ PPPYP 61_ QPPLP 66_ YGQAP 71_ DAAAA 76_ FPHLA 81_ GDPYG 86_ GLAPL 91_ AQPQP 96_ PQAAW 101_ AAPRA 106_ AARAH 111_ EEPPG 116_ LLAPP 121_ ARALG 126_ LDPRR 131_ DYATA 136_ VPRLL 141_ HGLAD 146_ GAHGL 151_ ADAPL 156_ GLPGL 161_ AAAPG 166_ LEDLQ 171_ AMDEP 176_ GMSLL 181_ DQSVI 186_ KKVPI 191_ PSKAS 196_ SLSAL 201_ SLAKD 206_ SLVGG 211_ ITNPG 216_ EVFCS 221_ VPGRL 226_ SLLSS 231_ TSKYK 236_ VTVGE 241_ VQRRL 246_ SPPEC 251_ LNASL 256_ LGGVL 261_ RRAKS 266_ KNGGR 271_ CLRER 276_ LEKIG 281_ LNLPA 286_ GRRKA 291_ ANVTL 296_ LTSLV 301_ EGEAV 306_ HLARD 311_ FGYVC 316_ ETEFP 321_ AKAAA 326_ EYLCR 331_ QHADP 336_ GELHS 341_ RKSML 346_ LAAKQ 351_ ICKEF 356_ ADLMA 361_ QDRSP 366_ LGNSR 371_ PALIL 376_ EPGVQ 381_ SCLTH 386_ FSLIT 391_ HGFGG 396_ PAICA 401_ ALTAF 406_ QNYLL 411_ ESLKG 416_ LDKMF 421_ LSSVG 426_ SGHGE 431_ TKASE 436_KDAKH
1: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity)