E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1)
1_MAAEA 6_ SESGP 11_ ALHEL 16_ MREAE 21_ ISLLE 26_ CKVCF 31_ EKFGH 36_ RQQRR 41_ PRNLS 46_ CGHVV 51_ CLACV 56_ AALAH 61_ PRTLA 66_ LECPF 71_ CRRAC 76_ RGCDT 81_ SDCLP 86_ VLHLI 91_ ELLGS 96_ ALRQS 101_ PAAHR 106_ AAPSA 111_ PGALT 116_ CHHTF 121_ GGWGT 126_ LVNPT 131_ GLALC 136_ PKTGR 141_ VVVVH 146_ DGRRR 151_ VKIFD 156_ SGGGC 161_ AHQFG 166_ EKGDA 171_ AQDIR 176_ YPVDV 181_ TITND 186_ CHVVV 191_ TDAGD 196_ RSIKV 201_ FDFFG 206_ QIKLV 211_ IGGQF 216_ SLPWG 221_ VETTP 226_ QNGIV 231_ VTDAE 236_ AGSLH 241_ LLDVD 246_ FAEGV 251_ LRRTE 256_ RLQAH 261_ LCNPR 266_ GVAVS 271_ WLTGA 276_ IAVLE 281_ HPLAL 286_ GTGVC 291_ STRVK 296_ VFSSS 301_ MQLVG 306_ QVDTF 311_ GLSLY 316_ FPSKI 321_ TASAV 326_ TFDHQ 331_ GNVIV 336_ ADTSG 341_ PAILC 346_ LGKPE 351_ EFPVP 356_ KPMVT 361_ HGLSH 366_ PVALT 371_ FTKEN 376_ SLLVL 381_ DTASH 386_SIKVY
1: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway