Phosphofurin acidic cluster sorting protein 1 (PACS-1)
1_MAERG 6_ GAGGG 11_ PGGAG 16_ GGSGQ 21_ RGSGV 26_ AQSPQ 31_ QPPPQ 36_ QQQQQ 41_ PPQQP 46_ TPPKL 51_ AQATS 56_ SSSST 61_ SAAAA 66_ SSSSS 71_ STSTS 76_ MAVAV 81_ ASGSA 86_ PPGGP 91_ GPGRT 96_ PAPVQ 101_ MNLYA 106_ TWEVD 111_ RSSSS 116_ CVPRL 121_ FSLTL 126_ KKLVM 131_ LKEMD 136_ KDLNS 141_ VVIAV 146_ KLQGS 151_ KRILR 156_ SNEIV 161_ LPASG 166_ LVETE 171_ LQLTF 176_ SLQYP 181_ HFLKR 186_ DANKL 191_ QIMLQ 196_ RRKRY 201_ KNRTI 206_ LGYKT 211_ LAVGL 216_ INMAE 221_ VMQHP 226_ NEGAL 231_ VLGLH 236_ SNVKD 241_ VSVPV 246_ AEIKI 251_ YSLSS 256_ QPIDH 261_ EGIKS 266_ KLSDR 271_ SPDID 276_ NYSEE 281_ EEESF 286_ SSEQE 291_ GSDDP 296_ LHGQD 301_ LFYED 306_ EDLRK 311_ VKKTR 316_ RKLTS 321_ TSAIT 326_ RQPNI 331_ KQKFV 336_ ALLKR 341_ FKVSD 346_ EVGFG 351_ LEHVS 356_ REQIR 361_ EVEED 366_ LDELY 371_ DSLEM 376_ YNPSD 381_ SGPEM 386_ EETES 391_ ILSTP 396_ KPKLK 401_ PFFEG 406_ MSQSS 411_ SQTEI 416_ GSLNS 421_ KGSLG 426_ KDTTS 431_ PMELA 436_ ALEKI 441_ KSTWI 446_ KNQDD 451_ SLTET 456_ DTLEI 461_ TDQDM 466_ FGDAS 471_ TSLVV 476_ PEKVK 481_ TPMKS 486_ SKTDL 491_ QGSAS 496_ PSKVE 501_ GVHTP 506_ RQKRS 511_ TPLKE 516_ RQLSK 521_ PLSER 526_ TNSSD 531_ SERSP 536_ DLGHS 541_ TQIPR 546_ KVVYD 551_ QLNQI 556_ LVSDA 561_ ALPEN 566_ VILVN 571_ TTDWQ 576_ GQYVA 581_ ELLQD 586_ QRKPV 591_ VCTCS 596_ TVEVQ 601_ AVLSA 606_ LLTRI 611_ QRYCN 616_ CNSSM 621_ PRPVK 626_ VAAVG 631_ GQSYL 636_ SSILR 641_ FFVKS 646_ LANKT 651_ SDWLG 656_ YMRFL 661_ IIPLG 666_ SHPVA 671_ KYLGS 676_ VDSKY 681_ SSSFL 686_ DSGWR 691_ DLFSR 696_ SEPPV 701_ SEQLD 706_ VAGRV 711_ MQYVN 716_ GAATT 721_ HQLPV 726_ AEAML 731_ TCRHK 736_ FPDED 741_ SYQKF 746_ IPFIG 751_ VVKVG 756_ LVEDS 761_ PSTAG 766_ DGDDS 771_ PVVSL 776_ TVPST 781_ SPPSS 786_ SGLSR 791_ DATAT 796_ PPSSP 801_ SMSSA 806_ LAIVG 811_ SPNSP 816_ YGDVI 821_ GLQVD 826_ YWLGH 831_ PGERR 836_ REGDK 841_ RDASS 846_ KNTLK 851_ SVFRS 856_ VQVSR 861_ LPHSG 866_ EAQLS 871_ GTMAM 876_ TVVTK 881_ EKNKK 886_ VPTIF 891_ LSKKP 896_ REKEV 901_ DSKSQ 906_ VIEGI 911_ SRLIC 916_ SAKQQ 921_ QTMLR 926_ VSIDG 931_ VEWSD 936_ IKFFQ 941_ LAAQW 946_ PTHVK 951_ HFPVG 956_LFSGS
1: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity)