Developmental pluripotency-associated protein 3 (Stella-related protein)
1_MDPSQ 6_ FNPTY 11_ IPGSP 16_ QMLTE 21_ ENSRD 26_ DSGAS 31_ QISSE 36_ TLIKN 41_ LSNLT 46_ INASS 51_ ESVSP 56_ LSEAL 61_ LRRES 66_ VGAAV 71_ LREIE 76_ DEWLY 81_ SRRGV 86_ RTLLS 91_ VQREK 96_ MARLR 101_ YMLLG 106_ GVRTH 111_ ERRPT 116_ NKEPK 121_ GVKKE 126_ SRPFK 131_ CPCSF 136_ CVSNG 141_ WDPSE 146_ NARIG 151_NQDTK
1: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:35314832). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process (By similarity). Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation (By similarity). Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark (By similarity). Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis (By similarity). May be important for the totipotent/pluripotent states continuing through preimplantation development (By similarity). Also involved in chromatin condensation in oocytogenesis (By similarity)