F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35)
1_MEIRL 6_ PDLAL 11_ KRIFS 16_ FLDLF 21_ GLLQV 26_ SQVNK 31_ HWNRI 36_ ADSDY 41_ LWRSL 46_ SLQRW 51_ DCSNF 56_ TNQHL 61_ GTHTW 66_ KQFFL 71_ HQRRK 76_ ELRLA 81_ LAQPH 86_ NFIYK 91_ VTKNI 96_ AFETE 101_ LAYLS 106_ GNRLT 111_ VDEQE 116_ KSIIC 121_ SVSPK 126_ QELCA 131_ WDVQE 136_ GTMIW 141_ SSPVQ 146_ EFHFS 151_ NLVTL 156_ PQMHL 161_ AITMD 166_ RKKTI 171_ KVWNC 176_ QDRDA 181_ LAVLP 186_ MPQPC 191_ YCMEA 196_ YLTKD 201_ GPFLM 206_ VGDAA 211_ GDIYT 216_ FTLPG 221_ LRDVS 226_ KVTAF 231_ QYGIV 236_ LLHCS 241_ PDKKW 246_ VFACG 251_ TYSRT 256_ LPQVF 261_ LTESL 266_ LRPSE 271_ GSVPL 276_ STFLP 281_ HKLCA 286_ SACWT 291_ PKVKN 296_ RITLM 301_ SQSST 306_ GKKTE 311_ FITFD 316_ LTTKK 321_ TGGQT 326_ VIQAY 331_ EIASF 336_ QVAAH 341_ LKCPI 346_ WMGAS 351_ DGYMI 356_ VFTSG 361_ PYLLL 366_ FSITG 371_ FLLQR 376_ FEDHQ 381_ AAINN 386_ FWVDP 391_ CYVLT 396_ TSENS 401_ VHVYM 406_ WEEGG 411_ RHPYL 416_ RSCCH 421_ LENTW 426_ HDHTT 431_ DSCIS 436_ SVMCD 441_ NASIV 446_ LRVRK 451_ VSDSS 456_ILVMY
1: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:26171402). Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination (PubMed:26171402). Functions as a cell growth suppressor (PubMed:26171402)