Zinc transporter 10 (ZnT-10) (Manganese transporter SLC30A10) (Solute carrier family 30 member 10)
1_MGRYS 6_ GKTCR 11_ LLFML 16_ VLTVA 21_ FFVAE 26_ LVSGY 31_ LGNSI 36_ ALLSD 41_ SFNML 46_ SDLIS 51_ LCVGL 56_ SAGYI 61_ ARRPT 66_ RGFSA 71_ TYGYA 76_ RAEVV 81_ GALSN 86_ AVFLT 91_ ALCFT 96_ IFVEA 101_ VLRLA 106_ RPERI 111_ DDPEL 116_ VLIVG 121_ VLGLL 126_ VNVVG 131_ LLIFQ 136_ DCAAW 141_ FACCL 146_ RGRSR 151_ RLQQR 156_ QQLAE 161_ GCVPG 166_ AFGGP 171_ QGAED 176_ PRRAA 181_ DPTAP 186_ GSDSA 191_ VTLRG 196_ TSVER 201_ KREKG 206_ ATVFA 211_ NVAGD 216_ SFNTQ 221_ NEPED 226_ MMKKE 231_ KKSEA 236_ LNIRG 241_ VLLHV 246_ MGDAL 251_ GSVVV 256_ VITAI 261_ IFYVL 266_ PLKSE 271_ DPCNW 276_ QCYID 281_ PSLTV 286_ LMVII 291_ ILSSA 296_ FPLIK 301_ ETAAI 306_ LLQMV 311_ PKGVN 316_ MEELM 321_ SKLSA 326_ VPGIS 331_ SVHEV 336_ HIWEL 341_ VSGKI 346_ IATLH 351_ IKYPK 356_ DRGYQ 361_ DASTK 366_ IREIF 371_ HHAGI 376_ HNVTI 381_ QFENV 386_ DLKEP 391_ LEQKD 396_ LLLLC 401_ NSPCI 406_ SKGCA 411_ KQLCC 416_ PPGAL 421_ PLAHV 426_ NGCAE 431_ HNGGP 436_ SLDTY 441_ GSDGL 446_ SRRDA 451_ REVAI 456_ EVSLD 461_ SCLSD 466_ HGQSL 471_ NKTQE 476_DQCYV
1: Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129)