Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
1_MEGDG 6_ VPWGS 11_ EPVSG 16_ PGPGG 21_ GGMIR 26_ ELCRG 31_ FGRYR 36_ RYLGR 41_ LRQNL 46_ RETQK 51_ FFRDI 56_ KCSHN 61_ HTCLS 66_ SLTGG 71_ GGAER 76_ GPAGD 81_ VAETG 86_ LQAGQ 91_ LSCIS 96_ FPPKE 101_ EKYLQ 106_ QIVDC 111_ LPCIL 116_ ILGQD 121_ CNVKC 126_ QLLNL 131_ LLGVQ 136_ VLPTT 141_ KLGSE 146_ ESCKL 151_ RRLRF 156_ TYGTQ 161_ TRVSL 166_ ALPGQ 171_ YELVH 176_ TLVAH 181_ QGNWE 186_ TIPEE 191_ DLEVQ 196_ ENNED 201_ AAHVL 206_ AELEV 211_ TMHHA 216_ LLQEV 221_ DVVVA 226_ PCQGL 231_ RPTVD 236_ VLGDL 241_ VNDFL 246_ PVITY 251_ ALHKD 256_ ELSER 261_ DEQEL 266_ QEIRK 271_ YFSFP 276_ VFFFK 281_ VPKLG 286_ SEIID 291_ SSTRR 296_ MESER 301_ SPLYR 306_ QLIDL 311_ GYLSS 316_ SHWNC 321_ GAPGQ 326_ DTKAQ 331_ SMLVE 336_ QSEKL 341_ RHLST 346_ FSHQV 351_ LQTRL 356_ VDAAK 361_ ALNLV 366_ HCHCL 371_ DIFIN 376_ QAFDM 381_ QRDLQ 386_ ITPKR 391_ LEYTR 396_ KKENE 401_ LYESL 406_ MNIAN 411_ RKQEE 416_ MKDMI 421_ VETLN 426_ TMKEE 431_ LLDDA 436_ TNMEF 441_ KDVIV 446_ PENGE 451_ PVGTR 456_ EIKCC 461_ IRQIQ 466_ ELIIS 471_ RLNQA 476_ VANKL 481_ ISSVD 486_ YLRES 491_ FVGTL 496_ ERCLQ 501_ SLEKS 506_ QDVSV 511_ HITSN 516_ YLKQI 521_ LNAAY 526_ HVEVT 531_ FHSGS 536_ SVTRM 541_ LWEQI 546_ KQIIQ 551_ RITWV 556_ SPPAI 561_ TLEWK 566_ RKVAQ 571_ EAIES 576_ LSASK 581_ LAKSI 586_ CSQFR 591_ TRLNS 596_ SHEAF 601_ AASLR 606_ QLEAG 611_ HSGRL 616_ EKTED 621_ LWLRV 626_ RKDHA 631_ PRLAR 636_ LSLES 641_ CSLQD 646_ VLLHR 651_ KPKLG 656_ QELGR 661_ GQYGV 666_ VYLCD 671_ NWGGH 676_ FPCAL 681_ KSVVP 686_ PDEKH 691_ WNDLA 696_ LEFHY 701_ MRSLP 706_ KHERL 711_ VDLHG 716_ SVIDY 721_ NYGGG 726_ SSIAV 731_ LLIME 736_ RLHRD 741_ LYTGL 746_ KAGLT 751_ LETRL 756_ QIALD 761_ VVEGI 766_ RFLHS 771_ QGLVH 776_ RDIKL 781_ KNVLL 786_ DKQNR 791_ AKITD 796_ LGFCK 801_ PEAMM 806_ SGSIV 811_ GTPIH 816_ MAPEL 821_ FTGKY 826_ DNSVD 831_ VYAFG 836_ ILFWY 841_ ICSGS 846_ VKLPE 851_ AFERC 856_ ASKDH 861_ LWNNV 866_ RRGAR 871_ PERLP 876_ VFDEE 881_ CWQLM 886_ EACWD 891_ GDPLK 896_ RPLLG 901_ IVQPM 906_ LQGIM 911_ NRLCK 916_ SNSEQ 921_PNRGL
1: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540)