Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B)
1_MAAVA 6_ ATAAA 11_ KGNGG 16_ GGGRA 21_ GAGDA 26_ SGTRK 31_ KKGPG 36_ PLATA 41_ YLVIY 46_ NVVMT 51_ AGWLV 56_ IAVGL 61_ VRAYL 66_ AKGSY 71_ HSLYY 76_ SIEKP 81_ LKFFQ 86_ TGALL 91_ EILHC 96_ AIGIV 101_ PSSVV 106_ LTSFQ 111_ VMSRV 116_ FLIWA 121_ VTHSV 126_ KEVQS 131_ EDSVL 136_ LFVIA 141_ WTITE 146_ IIRYS 151_ FYTFS 156_ LLNHL 161_ PYLIK 166_ WARYT 171_ LFIVL 176_ YPMGV 181_ SGELL 186_ TIYAA 191_ LPFVR 196_ QAGLY 201_ SISLP 206_ NKYNF 211_ SFDYY 216_ AFLIL 221_ IMISY 226_ IPIFP 231_ QLYFH 236_ MIHQR 241_ RKILS 246_HTEEH
1: Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators