Transmembrane protein 64
1_MRSPG 6_ GILLQ 11_ ALPRL 16_ LQHAA 21_ LPGLA 26_ ELPAR 31_ WALPR 36_ GAGGD 41_ GPADR 46_ LPRGG 51_ GASAA 56_ AAAAA 61_ ASGAL 66_ LGAYL 71_ ERHGP 76_ PEASE 81_ LPEPG 86_ GALAG 91_ GPGSG 96_ GGGVV 101_ VGVAE 106_ VRNWR 111_ CCCLG 116_ STCWC 121_ RSLVL 126_ VCVLA 131_ ALCFA 136_ SLALV 141_ RRYLH 146_ HLLLW 151_ VESLD 156_ SLLGV 161_ LLFVV 166_ GFIVV 171_ SFPCG 176_ WGYIV 181_ LNVAA 186_ GYLYG 191_ FVLGM 196_ GLMMV 201_ GVLIG 206_ TFIAH 211_ VVCKR 216_ LLTAW 221_ VAARI 226_ QSSEK 231_ LSAVI 236_ RVVEG 241_ GSGLK 246_ VVALA 251_ RLTPI 256_ PFGLQ 261_ NAVFS 266_ ITDLS 271_ LPNYL 276_ MASSV 281_ GLLPT 286_ QLLNS 291_ YLGTT 296_ LRTME 301_ DVIAE 306_ QSVSG 311_ YFVFC 316_ LQIII 321_ SIGLM 326_ FYVVH 331_ RAQVE 336_ LNAAI 341_ VACEM 346_ ELKSS 351_ LVKGN 356_ QPNTS 361_ GSSFY 366_ NKRTL 371_TFSGG
1: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1