Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)
1_MFLAQ 6_ RSLCS 11_ LSGRA 16_ KFLKT 21_ ISSSK 26_ ILGFS 31_ TSAKM 36_ SLKFT 41_ NAKRI 46_ EGLDS 51_ NVWIE 56_ FTKLA 61_ ADPSV 66_ VNLGQ 71_ GFPDI 76_ SPPTY 81_ VKEEL 86_ SKIAA 91_ IDSLN 96_ QYTRG 101_ FGHPS 106_ LVKAL 111_ SYLYE 116_ KLYQK 121_ QIDSN 126_ KEILV 131_ TVGAY 136_ GSLFN 141_ TIQAL 146_ IDEGD 151_ EVILI 156_ VPFYD 161_ CYEPM 166_ VRMAG 171_ ATPVF 176_ IPLRS 181_ KPVYG 186_ KRWSS 191_ SDWTL 196_ DPQEL 201_ ESKFN 206_ SKTKA 211_ IILNT 216_ PHNPL 221_ GKVYN 226_ REELQ 231_ VIADL 236_ CIKYD 241_ TLCIS 246_ DEVYE 251_ WLVYS 256_ GNKHL 261_ KIATF 266_ PGMWE 271_ RTITI 276_ GSAGK 281_ TFSVT 286_ GWKLG 291_ WSIGP 296_ NHLIK 301_ HLQTV 306_ QQNTI 311_ YTCAT 316_ PLQEA 321_ LAQAF 326_ WIDIK 331_ RMDDP 336_ ECYFN 341_ SLPKE 346_ LEVKR 351_ DRMVR 356_ LLESV 361_ GLKPI 366_ VPDGG 371_ YFIIA 376_ DVSLL 381_ DPDLS 386_ DMKNN 391_ EPYDY 396_ KFVKW 401_ MTKHK 406_ KLSAI 411_ PVSAF 416_ CNSET 421_ KSQFE 426_ KFVRF 431_ CFIKK 436_ DSTLD 441_ AAEEI 446_IKAWS
1: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)