Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)
1_MAGIL 6_ AWFWN 11_ ERFWL 16_ PHNVT 21_ WADLK 26_ NTEEA 31_ TFPQA 36_ EDLYL 41_ AFPLA 46_ FCIFM 51_ VRLIF 56_ ERFVA 61_ KPCAI 66_ ALNIQ 71_ ANGPQ 76_ IAPPN 81_ AILEK 86_ VFTAI 91_ TKHPD 96_ EKRLE 101_ GLSKQ 106_ LDWDV 111_ RSIQR 116_ WFRQR 121_ RNQEK 126_ PSTLT 131_ RFCES 136_ MWRFS 141_ FYLYV 146_ FTYGV 151_ RFLKK 156_ TPWLW 161_ NTRHC 166_ WYNYP 171_ YQPLT 176_ TDLHY 181_ YYILE 186_ LSFYW 191_ SLMFS 196_ QFTDI 201_ KRKDF 206_ GIMFL 211_ HHLVS 216_ IFLIT 221_ FSYVN 226_ NMARV 231_ GTLVL 236_ CLHDS 241_ ADALL 246_ EAAKM 251_ ANYAK 256_ FQKMC 261_ DLLFV 266_ MFAVV 271_ FITTR 276_ LGIFP 281_ LWVLN 286_ TTLFE 291_ SWEIV 296_ GPYPS 301_ WWVFN 306_ LLLLL 311_ VQGLN 316_ CFWSY 321_ LIVKI 326_ ACKAV 331_ SRGKV 336_ SKDDR 341_ SDIES 346_ SSDEE 351_ DSEPP 356_ GKNPH 361_ TATTT 366_ NGTSG 371_ TNGYL 376_LTGSC
1: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17609214, PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity)