Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5)
1_MMGSP 6_ VSHLL 11_ AGFCV 16_ WVVLG 21_ WVGGS 26_ VPNLG 31_ PAEQE 36_ QNHYL 41_ AQLFG 46_ LYGEN 51_ GTLTA 56_ GGLAR 61_ LLHSL 66_ GLGRV 71_ QGLRL 76_ GQHGP 81_ LTGRA 86_ ASPAA 91_ DNSTH 96_ RPQNP 101_ ELSVD 106_ VWAGM 111_ PLGPS 116_ GWGDL 121_ EESKA 126_ PHLPR 131_ GPAPS 136_ GLDLL 141_ HRLLL 146_ LDHSL 151_ ADHLN 156_ EDCLN 161_ GSQLL 166_ VNFGL 171_ SPAAP 176_ LTPRQ 181_ FALLC 186_ PALLY 191_ QIDSR 196_ VCIGA 201_ PAPAP 206_ PGDLL 211_ SALLQ 216_ SALAV 221_ LLLSL 226_ PSPLS 231_ LLLLR 236_ LLGPR 241_ LLRPL 246_ LGFLG 251_ ALAVG 256_ TLCGD 261_ ALLHL 266_ LPHAQ 271_ EGRHA 276_ GPGGL 281_ PEKDL 286_ GPGLS 291_ VLGGL 296_ FLLFV 301_ LENML 306_ GLLRH 311_ RGLRP 316_ RCCRR 321_ KRRNL 326_ ETRNL 331_ DPENG 336_ SGMAL 341_ QPLQA 346_ APEPG 351_ AQGQR 356_ EKNSQ 361_ HPPAL 366_ APPGH 371_ QGHSH 376_ GHQGG 381_ TDITW 386_ MVLLG 391_ DGLHN 396_ LTDGL 401_ AIGAA 406_ FSDGF 411_ SSGLS 416_ TTLAV 421_ FCHEL 426_ PHELG 431_ DFAML 436_ LQSGL 441_ SFRRL 446_ LLLSL 451_ VSGAL 456_ GLGGA 461_ VLGVG 466_ LSLGP 471_ VPLTP 476_ WVFGV 481_ TAGVF 486_ LYVAL 491_ VDMLP 496_ ALLRP 501_ PEPLP 506_ TPHVL 511_ LQGLG 516_ LLLGG 521_ GLMLA 526_ ITLLE 531_ERLLP
1: Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (By similarity). The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Plays a role in eye development (PubMed:24891338)