Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1)
1_MASAE 6_ LQGKY 11_ QKLAQ 16_ EYSKL 21_ RAQNQ 26_ VLKKG 31_ VVDEQ 36_ ANSAA 41_ LKEQL 46_ KMKDQ 51_ SLRKL 56_ QQEMD 61_ SLTFR 66_ NLQLA 71_ KRVEL 76_ LQDEL 81_ ALSEP 86_ RGKKN 91_ KKSGE 96_ SSSQL 101_ SQEQK 106_ SVFDE 111_ DLQKK 116_ IEENE 121_ RLHIQ 126_ FFEAD 131_ EQHKH 136_ VEAEL 141_ RSRLA 146_ TLETE 151_ AAQHQ 156_ AVVDG 161_ LTRKY 166_ METIE 171_ KLQND 176_ KAKLE 181_ VKSQT 186_ LEKEA 191_ KECRL 196_ RTEEC 201_ QLQLK 206_ TLHED 211_ LSGRL 216_ EESLS 221_ IINEK 226_ VPFND 231_ TKYSQ 236_ YNALN 241_ VPLHN 246_ RRHQL 251_ KMRDI 256_ AGQAL 261_ AFVQD 266_ LVTAL 271_ LNFHT 276_ YTEQR 281_ IQIFP 286_ VDSAI 291_ DTISP 296_ LNQKF 301_ SQYLH 306_ ENASY 311_ VRPLE 316_ EGMLH 321_ LFESI 326_ TEDTV 331_ TVLET 336_ TVKLK 341_ TFSEH 346_ LTSYI 351_ CFLRK 356_ ILPYQ 361_ LKSLE 366_ EECES 371_ SLCTS 376_ ALRAR 381_ NLELS 386_ QDMKK 391_ MTAVF 396_ EKLQT 401_ YIALL 406_ ALPST 411_ EPDGL 416_ LRTNY 421_ SSVLT 426_ NVGAA 431_ LHGFH 436_ DVMKD 441_ ISKHY 446_ SQKAA 451_ IEHEL 456_ PTATQ 461_ KLITT 466_ NDCIL 471_ SSVVA 476_ LTNGA 481_ GKIAS 486_ FFSNN 491_ LDYFI 496_ ASLSY 501_ GPKAA 506_ SGFIS 511_ PLSAE 516_ CMLQY 521_ KKKAA 526_ AYMKS 531_ LRKPL 536_ LESVP 541_ YEEAL 546_ ANRRI 551_ LLSST 556_ ESREG 561_ LAQQV 566_ QQSLE 571_ KISKL 576_ EQEKE 581_ HWMLE 586_ AQLAK 591_ IKLEK 596_ ENQRI 601_ ADKLK 606_ NTGSA 611_ QLVGL 616_ AQENA 621_ AVSNT 626_ AGQDE 631_ ATAKA 636_ VLEPI 641_ QSTSL 646_ IGTLT 651_ RTSDS 656_ EVPDV 661_ ESRED 666_ LIKNH 671_ YMARI 676_ VELTS 681_ QLQLA 686_ DSKSV 691_ HFYAE 696_ CRALS 701_ KRLAL 706_ AEKSK 711_ EALTE 716_ EMKLA 721_ SQNIS 726_ RLQDE 731_ LTTTK 736_ RSYED 741_ QLSMM 746_ SDHLC 751_ SMNET 756_ LSKQR 761_ EEIDT 766_ LKMSS 771_KGNSK
1: Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (PubMed:37267906). Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (Probable) (PubMed:30520571)