Gliomedin [Cleaved into: Gliomedin shedded ectodomain]
1_MARGA 6_ EGGRG 11_ DAGWG 16_ LRGAL 21_ AAVAL 26_ LSALN 31_ AAGTV 36_ FALCQ 41_ WRGLS 46_ SALRA 51_ LEAQR 56_ GREQR 61_ EDSAL 66_ RSFLA 71_ ELSRA 76_ PRGAS 81_ APPQD 86_ PASSA 91_ RNKRS 96_ HSGEP 101_ APHIR 106_ AESHD 111_ MLMMM 116_ TYSMV 121_ PIRVM 126_ VDLCN 131_ STKGI 136_ CLTGP 141_ SGPPG 146_ PPGAG 151_ GLPGH 156_ NGLDG 161_ QPGPQ 166_ GPKGE 171_ KGANG 176_ KRGKM 181_ GIPGA 186_ AGNPG 191_ ERGEK 196_ GDHGE 201_ LGLQG 206_ NEGPP 211_ GQKGE 216_ KGDKG 221_ DVSND 226_ VLLAG 231_ AKGDQ 236_ GPPGP 241_ PGPPG 246_ PPGPP 251_ GPPGS 256_ RRAKG 261_ PRQPS 266_ MFNGQ 271_ CPGET 276_ CAIPN 281_ DDTLV 286_ GKADE 291_ KASEH 296_ HSPQA 301_ ESMIT 306_ SIGNP 311_ VQVLK 316_ VTETF 321_ GTWIR 326_ ESANK 331_ SDDRI 336_ WVTEH 341_ FSGIM 346_ VKEFK 351_ DQPSL 356_ LNGSY 361_ TFIHL 366_ PYYFH 371_ GCGHV 376_ VYNNS 381_ LYYHK 386_ GGSNT 391_ LVRFE 396_ FGQET 401_ SQTLK 406_ LENAL 411_ YFDRK 416_ YLFAN 421_ SKTYF 426_ NLAVD 431_ EKGLW 436_ IIYAS 441_ SVDGS 446_ SILVA 451_ QLDER 456_ TFSVV 461_ QHVNT 466_ TYPKS 471_ KAGNA 476_ FIARG 481_ ILYVT 486_ DTKDM 491_ RVTFA 496_ FDLLG 501_ GKQIN 506_ ANFDL 511_ RTSQS 516_ VLAML 521_ AYNMR 526_ DQHLY 531_ SWEDG 536_ HLMLY 541_ PVQFL 546_STTLN
1: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier