Gene name: IL34

Uniprot entry:

Q6ZMJ4

Protein names:

Interleukin-34 (IL-34)

Protein sequence:

1_MPRGF 6_ TWLRY 11_ LGIFL 16_ GVALG 21_ NEPLE 26_ MWPLT 31_ QNEEC 36_ TVTGF 41_ LRDKL 46_ QYRSR 51_ LQYMK 56_ HYFPI 61_ NYKIS 66_ VPYEG 71_ VFRIA 76_ NVTRL 81_ QRAQV 86_ SEREL 91_ RYLWV 96_ LVSLS 101_ ATESV 106_ QDVLL 111_ EGHPS 116_ WKYLQ 121_ EVETL 126_ LLNVQ 131_ QGLTD 136_ VEVSP 141_ KVESV 146_ LSLLN 151_ APGPN 156_ LKLVR 161_ PKALL 166_ DNCFR 171_ VMELL 176_ YCSCC 181_ KQSSV 186_ LNWQD 191_ CEVPS 196_ PQSCS 201_ PEPSL 206_ QYAAT 211_ QLYPP 216_ PPWSP 221_ SSPPH 226_ STGSV 231_ RPVRA 236_QGEGL

Protein annotations

Protein functions:

1: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1