Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)
1_MAGAA 6_ AAVAA 11_ GAAAG 16_ AAAAA 21_ VSVAA 26_ PGRAS 31_ APPPP 36_ PPVYC 41_ VCRQP 46_ YDVNR 51_ FMIEC 56_ DICKD 61_ WFHGS 66_ CVGVE 71_ EHHAV 76_ DIDLY 81_ HCPNC 86_ AVLHG 91_ SSLMK 96_ KRRNW 101_ HRHDY 106_ TEIDD 111_ GSKPV 116_ QAGTR 121_ TFIKE 126_ LRSRV 131_ FPSAD 136_ EIIIK 141_ MHGSQ 146_ LTQRY 151_ LEKHG 156_ FDVPI 161_ MVPKL 166_ DDLGL 171_ RLPSP 176_ TFSVM 181_ DVERY 186_ VGGDK 191_ VIDVI 196_ DVARQ 201_ ADSKM 206_ TLHNY 211_ VKYFM 216_ NPNRP 221_ KVLNV 226_ ISLEF 231_ SDTKM 236_ SELVE 241_ VPDIA 246_ KKLSW 251_ VENYW 256_ PDDSV 261_ FPKPF 266_ VQKYC 271_ LMGVQ 276_ DSYTD 281_ FHIDF 286_ GGTSV 291_ WYHVL 296_ WGEKI 301_ FYLIK 306_ PTDEN 311_ LARYE 316_ SWSSS 321_ VTQSE 326_ VFFGD 331_ KVDKC 336_ YKCVV 341_ KQGHT 346_ LFVPT 351_ GWIHA 356_ VLTSQ 361_ DCMAF 366_ GGNFL 371_ HNLNI 376_ GMQLR 381_ CYEME 386_ KRLKT 391_ PDLFK 396_ FPFFE 401_ AICWF 406_ VAKNL 411_ LETLK 416_ ELRED 421_ GFQPQ 426_ TYLVQ 431_ GVKAL 436_ HTALK 441_ LWMKK 446_ ELVSE 451_ HAFEI 456_ PDNVR 461_ PGHLI 466_ KELSK 471_ VIRAI 476_ EEENG 481_ KPVKS 486_ QGIPI 491_ VCPVS 496_ RSSNE 501_ ATSPY 506_ HSRRK 511_ MRKLR 516_ DHNVR 521_ TPSNL 526_ DILEL 531_ HTREV 536_ LKRLE 541_ MCPWE 546_ EDILS 551_ SKLNG 556_ KFNKH 561_ LQPSS 566_ TVPEW 571_ RAKDN 576_ DLRLL 581_ LTNGR 586_ IIKDE 591_ RQPFA 596_ DQSLY 601_ TADSE 606_ NEEDK 611_ RRTKK 616_ AKMKI 621_ EESSG 626_ VEGVE 631_ HEESQ 636_ KPLNG 641_ FFTRV 646_ KSELR 651_ SRSSG 656_ YSDIS 661_ ESEDS 666_ GPECT 671_ ALKSI 676_ FTTEE 681_ SESSG 686_ DEKKQ 691_ EITSN 696_ FKEES 701_ NVMRN 706_ FLQKS 711_ QKPSR 716_ SEIPI 721_ KRECP 726_ TSTST 731_ EEEAI 736_ QGMLS 741_ MAGLH 746_ YSTCL 751_ QRQIQ 756_ STDCS 761_ GERNS 766_ LQDPS 771_ SCHGS 776_ NHEVR 781_ QLYRY 786_ DKPVE 791_ CGYHV 796_ KTEDP 801_ DLRTS 806_ SWIKQ 811_ FDTSR 816_ FHPQD 821_ LSRSQ 826_ KCIRK 831_ EGSSE 836_ ISQRV 841_ QSRNY 846_ VDSSG 851_ SSLQN 856_ GKYMQ 861_ NSNLT 866_ SGACQ 871_ ISNGS 876_ LSPER 881_ PVGET 886_ SFSVP 891_ LHPTK 896_ RPASN 901_ PPPIS 906_ NQATK 911_ GKRPK 916_ KGMAT 921_ AKQRL 926_ GKILK 931_ LNRNG 936_HARFF
1: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (PubMed:20023638, PubMed:20622853). Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 (PubMed:20023638). Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (PubMed:20622853)