Tripartite motif-containing protein 72 (Mitsugumin-53) (Mg53)
1_MSAAP 6_ GLLHQ 11_ ELSCP 16_ LCLQL 21_ FDAPV 26_ TAECG 31_ HSFCR 36_ ACLGR 41_ VAGEP 46_ AADGT 51_ VLCPC 56_ CQAPT 61_ RPQAL 66_ STNLQ 71_ LARLV 76_ EGLAQ 81_ VPQGH 86_ CEEHL 91_ DPLSI 96_ YCEQD 101_ RALVC 106_ GVCAS 111_ LGSHR 116_ GHRLL 121_ PAAEA 126_ HARLK 131_ TQLPQ 136_ QKLQL 141_ QEACM 146_ RKEKS 151_ VAVLE 156_ HQLVE 161_ VEETV 166_ RQFRG 171_ AVGEQ 176_ LGKMR 181_ VFLAA 186_ LEGSL 191_ DREAE 196_ RVRGE 201_ AGVAL 206_ RRELG 211_ SLNSY 216_ LEQLR 221_ QMEKV 226_ LEEVA 231_ DKPQT 236_ EFLMK 241_ YCLVT 246_ SRLQK 251_ ILAES 256_ PPPAR 261_ LDIQL 266_ PIISD 271_ DFKFQ 276_ VWRKM 281_ FRALM 286_ PALEE 291_ LTFDP 296_ SSAHP 301_ SLVVS 306_ SSGRR 311_ VECSE 316_ QKAPP 321_ AGEDP 326_ RQFDK 331_ AVAVV 336_ AHQQL 341_ SEGEH 346_ YWEVD 351_ VGDKP 356_ RWALG 361_ VIAAE 366_ APRRG 371_ RLHAV 376_ PSQGL 381_ WLLGL 386_ REGKI 391_ LEAHV 396_ EAKEP 401_ RALRS 406_ PERRP 411_ TRIGL 416_ YLSFG 421_ DGVLS 426_ FYDAS 431_ DADAL 436_ VPLFA 441_ FHERL 446_ PRPVY 451_ PFFDV 456_ CWHDK 461_ GKNAQ 466_ PLLLV 471_GPEGA
1: Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)