E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)
1_MGSEK 6_ DSESP 11_ RSTSL 16_ HAAAP 21_ DPKCR 26_ SGGRR 31_ RRLTL 36_ HSVFS 41_ ASARG 46_ RRARA 51_ KPQAE 56_ PPPPA 61_ AQPPP 66_ APAPA 71_ AAQGP 76_ PPEAL 81_ PAEPA 86_ AEAEA 91_ EAAAA 96_ AAEPG 101_ FDDEE 106_ AAEGG 111_ GPGAE 116_ EVECP 121_ LCLVR 126_ LPPER 131_ APRLL 136_ SCPHR 141_ SCRDC 146_ LRHYL 151_ RLEIS 156_ ESRVP 161_ ISCPE 166_ CSERL 171_ NPHDI 176_ RLLLA 181_ DPPLM 186_ HKYEE 191_ FMLRR 196_ YLASD 201_ PDCRW 206_ CPAPD 211_ CGYAV 216_ IAYGC 221_ ASCPK 226_ LTCER 231_ EGCQT 236_ EFCYH 241_ CKQIW 246_ HPNQT 251_ CDMAR 256_ QQRAQ 261_ TLRVR 266_ TKHTS 271_ GLSYG 276_ QESGP 281_ ADDIK 286_ PCPRC 291_ SAYII 296_ KMNDG 301_ SCNHM 306_ TCAVC 311_ GCEFC 316_ WLCMK 321_ EISDL 326_ HYLSP 331_ SGCTF 336_ WGKKP 341_ WSRKK 346_ KILWQ 351_ LGTLI 356_ GAPVG 361_ ISLIA 366_ GIAIP 371_ AMVIG 376_ IPVYV 381_ GRKIH 386_ SRYEG 391_ RKTSK 396_ HKRNL 401_ AITGG 406_ VTLSV 411_ IASPV 416_ IAAVS 421_ VGIGV 426_ PIMLA 431_ YVYGV 436_ VPISL 441_ CRGGG 446_ CGVST 451_ ANGKG 456_ VKIEF 461_ DEDDG 466_ PITVA 471_ DAWRA 476_ LKNPS 481_ IGESS 486_ IEGLT 491_ SVLST 496_ SGSPT 501_ DGLSV 506_ MQGPY 511_ SETAS 516_ FAALS 521_ GGTLS 526_ GGILS 531_ SGKGK 536_ YSRLE 541_ VQADV 546_ QKEIF 551_ PKDTA 556_ SLGAI 561_ SDNAS 566_ TRAMA 571_ GSIIS 576_ SYNPQ 581_ DRECN 586_ NMEIQ 591_ VDIEA 596_ KPSHY 601_ QLVSG 606_ SSTED 611_ SLHVH 616_ AQMAE 621_ NEEEG 626_ SGGGG 631_ SEEDP 636_ PCRHQ 641_ SCEQK 646_ DCLAS 651_ KPWDI 656_ SLAQP 661_ ESIRS 666_ DLESS 671_ DAQSD 676_ DVPDI 681_ TSDEC 686_ GSPRS 691_ HTAAC 696_ PSTPR 701_ AQGAP 706_ SPSAH 711_ MNLSA 716_ LAEGQ 721_ TVLKP 726_EGGEA
1: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036)