Nesprin-3 (KASH domain-containing protein 3) (KASH3) (Nuclear envelope spectrin repeat protein 3)
1_MTQQP 6_ QDDFD 11_ RSVED 16_ AQAWM 21_ KAVQD 26_ QLQVN 31_ DNTQG 36_ PRAAL 41_ EARLW 46_ ETEKI 51_ CQLEP 56_ EGRVR 61_ VDLVL 66_ RMAEA 71_ LLACC 76_ PGDQK 81_ PGILA 86_ RLKDI 91_ KAQWE 96_ ETVTY 101_ MTHCH 106_ SRIEW 111_ VWLHW 116_ SEYLL 121_ ARDEF 126_ YRWFQ 131_ KMMVT 136_ LEPHI 141_ ELQLG 146_ LKEKQ 151_ WQLSH 156_ AQVLL 161_ HNVDN 166_ QAVLL 171_ DRLLE 176_ EAASL 181_ FNRIG 186_ DPSVD 191_ EDAQK 196_ RMKAE 201_ YDAVK 206_ AKAQK 211_ RVDLL 216_ EQVAR 221_ EHEEY 226_ QAGVD 231_ EFQLW 236_ LKAVV 241_ EKVNG 246_ CLGRN 251_ CKLPI 256_ TQRLS 261_ TLQDI 266_ AKDFP 271_ RGEES 276_ LETLE 281_ EQSAG 286_ VIRNT 291_ SPLGA 296_ EKITG 301_ ELEEM 306_ RKVLE 311_ KLRAL 316_ WEEEE 321_ ERLRG 326_ LLRSR 331_ GAWEQ 336_ QIKQL 341_ EAELS 346_ EFRMV 351_ LQRLA 356_ QEGLQ 361_ PAAKA 366_ GTEDE 371_ LVAHW 376_ RRYSA 381_ TRAAL 386_ ASEEP 391_ RVDRL 396_ QAQLK 401_ ELIVF 406_ PHNLK 411_ PLSDS 416_ VIATI 421_ QEYQS 426_ LKVKS 431_ ARLRN 436_ AAAVE 441_ LWQHF 446_ QRPLQ 451_ DLQLW 456_ KALAQ 461_ RLLEV 466_ TASLP 471_ DLPSL 476_ HTFLP 481_ QIEAA 486_ LMESS 491_ RLKEL 496_ LTMLQ 501_ LKKDL 506_ LIGIF 511_ GQERA 516_ TALLE 521_ QVAGS 526_ MRDRD 531_ LLHNS 536_ LLQRK 541_ SKLQS 546_ LLAQH 551_ KDFGA 556_ AFEPL 561_ QRKLL 566_ DLQVR 571_ VQAEK 576_ GLQRD 581_ LPGKQ 586_ AQLSR 591_ LQGLQ 596_ EEGLD 601_ LGAQM 606_ EAARP 611_ LVQEN 616_ PNHQH 621_ KMDQL 626_ SSDFQ 631_ ALQRS 636_ LEDLV 641_ DRCRQ 646_ SVQEH 651_ CTFSH 656_ QLLEL 661_ RQWIV 666_ VTTQK 671_ LEAHR 676_ GEAGP 681_ GDAES 686_ QEAEF 691_ ERLVA 696_ EFPEK 701_ EAQLS 706_ LVEAQ 711_ GWLVM 716_ EKSSP 721_ EGAAV 726_ VQEEL 731_ RELAE 736_ SWRAL 741_ RLLEE 746_ SLLSL 751_ IRNWH 756_ LQRME 761_ VDSGK 766_ KMVFT 771_ NNIPK 776_ SGFLI 781_ NPMDP 786_ IPRHR 791_ RRANL 796_ LQEEE 801_ GSHED 806_ FSQLL 811_ RNFGQ 816_ WLQVE 821_ NSKLV 826_ RIIAM 831_ RTSTA 836_ EDLRT 841_ RKSKL 846_ QELEA 851_ RVPEG 856_ QHLFE 861_ NLLRL 866_ GPARG 871_ TSDEL 876_ EDLRY 881_ QWMLY 886_ KSKLK 891_ DSGHL 896_ LTQSS 901_ PGEPT 906_ GFQKT 911_ RRWRG 916_ LGSLF 921_ RRACC 926_ VALPL 931_ QLLLL 936_ LFLLL 941_ LFLLP 946_ IREED 951_ RSCTL 956_ ANNFA 961_ RSFTL 966_MLRYN
1: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells