E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)
1_MSQWT 6_ PEYNE 11_ LYTLK 16_ VDMKS 21_ EIPSD 26_ APKTQ 31_ ESLKG 36_ ILLHP 41_ EPIGA 46_ AKSFP 51_ AGVEM 56_ INSKV 61_ GNEFS 66_ HLCDD 71_ SQKQE 76_ KEMNG 81_ NQQEQ 86_ EKSLV 91_ VRKKR 96_ KSQQA 101_ GPSYV 106_ QNCVK 111_ ENQGI 116_ LGLRQ 121_ HLGTP 126_ SDEDN 131_ DSSFS 136_ DCLSS 141_ PSSSL 146_ HFGDS 151_ DTVTS 156_ DEDKE 161_ VSVRH 166_ SQTIL 171_ NAKSR 176_ SHSAR 181_ SHKWP 186_ RTETE 191_ SVSGL 196_ LMKRP 201_ CLHGS 206_ SLRRL 211_ PCRKR 216_ FVKNN 221_ SSQRT 226_ QKQKE 231_ RILMQ 236_ RKKRE 241_ VLARR 246_ KYALL 251_ PSSSS 256_ SSEND 261_ LSSES 266_ SSSSS 271_ TEGEE 276_ DLFVS 281_ ASENH 286_ QNNPA 291_ VPSGS 296_ IDEDV 301_ VVIEA 306_ SSTPQ 311_ VTANE 316_ EINVT 321_ STDSE 326_ VEIVT 331_ VGESY 336_ RSRST 341_ LGHSR 346_ SHWSQ 351_ GSSSH 356_ ASRPQ 361_ EPRNR 366_ SRIST 371_ VIQPL 376_ RQNAA 381_ EVVDL 386_ TVDED 391_ EPTVV 396_ PTTSA 401_ RMESQ 406_ ATSAS 411_ INNSN 416_ PSTSE 421_ QASDT 426_ ASAVT 431_ SSQPS 436_ TVSET 441_ SATLT 446_ SNSTT 451_ GTSIG 456_ DDSRR 461_ TTSSA 466_ VTETG 471_ PPAMP 476_ RLPSC 481_ CPQHS 486_ PCGGS 491_ SQNHH 496_ ALGHP 501_ HTSCF 506_ QQHGH 511_ HFQHH 516_ HHHHH 521_ TPHPA 526_ VPVSP 531_ SFSDP 536_ ACPVE 541_ RPPQV 546_ QAPCG 551_ ANSSS 556_ GTSYH 561_ EQQAL 566_ PVDLS 571_ NSGIR 576_ SHGSG 581_ SFHGA 586_ SAFDP 591_ CCPVS 596_ SSRAA 601_ IFGHQ 606_ AAAAA 611_ PSQPL 616_ SSIDG 621_ YGSSM 626_ VAQPQ 631_ PQPPP 636_ QPSLS 641_ SCRHY 646_ MPPPY 651_ ASLTR 656_ PLHHQ 661_ ASACP 666_ HSHGN 671_ PPPQT 676_ QPPPQ 681_ VDYVI 686_ PHPVH 691_ AFHSQ 696_ ISSHA 701_ TSHPV 706_ APPPP 711_ THLAS 716_ TAAPI 721_ PQHLP 726_ PTHQP 731_ ISHHI 736_ PATAP 741_ PAQRL 746_ HPHEV 751_ MQRME 756_ VQRRR 761_ MMQHP 766_ TRAHE 771_ RPPPH 776_ PHRMH 781_ PNYGH 786_ GHHIH 791_ VPQTM 796_ SSHPR 801_ QAPER 806_ SAWEL 811_ GIEAG 816_ VTAAT 821_ YTPGA 826_ LHPHL 831_ AHYHA 836_ PPRLH 841_ HLQLG 846_ ALPLM 851_ VPDMA 856_ GYPHI 861_ RYISS 866_ GLDGT 871_ SFRGP 876_ FRGNF 881_ EELIH 886_ LEERL 891_ GNVNR 896_ GASQG 901_ TIERC 906_ TYPHK 911_ YKKVT 916_ TDWFS 921_ QRKLH 926_ CKQDG 931_ EEGTE 936_ EDTEE 941_ KCTIC 946_ LSILE 951_ EGEDV 956_ RRLPC 961_ MHLFH 966_ QVCVD 971_ QWLIT 976_ NKKCP 981_ ICRVD 986_IEAQL
1: E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)