Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)
1_MASPS 6_ GKGAR 11_ ALEAP 16_ GCGPR 21_ PLARD 26_ LVDSV 31_ DDAEG 36_ LYVAV 41_ ERCPL 46_ CNTTR 51_ RRLTC 56_ AKCVQ 61_ SGDFV 66_ YFDGR 71_ DRERF 76_ IDKKE 81_ RLSRL 86_ KSKQE 91_ EFQKE 96_ VLKAM 101_ EGKWI 106_ TDQLR 111_ WKIMS 116_ CKMRI 121_ EQLKQ 126_ TICKG 131_ NEEME 136_ KNSEG 141_ LLKTK 146_ EKNQK 151_ LYSRA 156_ QRHQE 161_ KKEKI 166_ QRHNR 171_ KLGDL 176_ VEKKT 181_ IDLRS 186_ HYERL 191_ ANLRR 196_ SHILE 201_ LTSVI 206_ FPIEE 211_ VKTGV 216_ RDPAD 221_ VSSES 226_ DSAMT 231_ SSTVS 236_ KLAEA 241_ RRTTY 246_ LSGRW 251_ VCDDH 256_ NGDTS 261_ ISITG 266_ PWISL 271_ PNNGD 276_ YSAYY 281_ SWVEE 286_ KKTTQ 291_ GPDME 296_ QSNPA 301_ YTISA 306_ ALCYA 311_ TQLVN 316_ ILSHI 321_ LDVNL 326_ PKKLC 331_ NSEFC 336_ GENLS 341_ KQKFT 346_ RAVKK 351_ LNANI 356_ LYLCF 361_ SQHVN 366_ LDQLQ 371_ PLHTL 376_ RNLMY 381_ LVSPS 386_ SEHLG 391_ RSGPF 396_ EVRAD 401_ LEESM 406_ EFVDP 411_ GVAGE 416_ SDESG 421_ DERVS 426_ DEETD 431_ LGTDW 436_ ENLPS 441_ PRFCD 446_ IPSQS 451_ VEVSQ 456_ SQSTQ 461_ ASPPI 466_ ASSSA 471_ GGMIS 476_ SAAAS 481_ VTSWF 486_KAYTG
1: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604, PubMed:37632749). Modulates the hepatic lipid metabolism (By similarity)