RUN and FYVE domain-containing protein 4
1_MAEEG 6_ AILKV 11_ TKDLR 16_ AAVSA 21_ ILQGY 26_ GDGQG 31_ PVTDT 36_ SAELH 41_ RLCGC 46_ LELLL 51_ QFDQK 56_ EQKSF 61_ LGPRK 66_ DYWDF 71_ LCTAL 76_ RRQRG 81_ NMEPI 86_ HFVRS 91_ QDKLK 96_ TPLGK 101_ GRAFI 106_ RFCLA 111_ RGQLA 116_ EALQL 121_ CLLNS 126_ ELTRE 131_ WYGPR 136_ SPLLC 141_ PERQE 146_ DILDS 151_ LYALN 156_ GVAFE 161_ LDLQQ 166_ PDLDG 171_ AWPMF 176_ SESRC 181_ SSSTQ 186_ TQGRR 191_ PRKNK 196_ DAPKK 201_ IPAAY 206_ GGPEN 211_ VQIED 216_ SHTSQ 221_ AICLQ 226_ DAPSG 231_ QQLAG 236_ LPRSQ 241_ QQRHL 246_ PFFLE 251_ KKGES 256_ SRKHR 261_ YPQSM 266_ WEPEG 271_ KELQL 276_ DQEER 281_ APWIE 286_ IFLGN 291_ STPST 296_ QGQGK 301_ GAMGT 306_ QKEVI 311_ GMEAE 316_ VTGVL 321_ LVAEG 326_ QRTTE 331_ GTHKK 336_ EAEWS 341_ HVQRL 346_ LMPSP 351_ RGAVE 356_ GAVSG 361_ SRQGS 366_ GGSSI 371_ LGEPW 376_ VLQGH 381_ ATKED 386_ STVEN 391_ PQVQT 396_ EVTLV 401_ ARREE 406_ QAEVS 411_ LQDEI 416_ KSLRL 421_ GLRKA 426_ EEQAQ 431_ RQEQL 436_ LREQE 441_ GELQA 446_ LREQL 451_ SRCQE 456_ ERAEL 461_ QAQLE 466_ QKQQE 471_ AERRD 476_ AMYQE 481_ ELGGQ 486_ RDLVQ 491_ AMKRR 496_ VLELI 501_ QEKDR 506_ LWQRL 511_ QHLSS 516_ MAPEC 521_ CVACS 526_ KIFGR 531_ FSRRY 536_ PCRLC 541_ GGLLC 546_ HACSM 551_ DYKKR 556_ DRCCP 561_ PCAQG 566_REAQV
1: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger (PubMed:26416964). Positive regulator of osteosclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes (By similarity)