Shieldin complex subunit 3 (REV7-interacting novel NHEJ regulator 1) (Shield complex subunit 3)
1_MTTEV 6_ ILHYR 11_ PCESD 16_ PTQLP 21_ KIAEK 26_ AIQDF 31_ PTRPL 36_ SRFIP 41_ WFPYD 46_ GSKLP 51_ LRPKR 56_ SPPVI 61_ SEEAA 66_ EDVKQ 71_ YLTIS 76_ EHDAK 81_ SHSYD 86_ CTVDL 91_ LEFQP 96_ SLKKQ 101_ HLTWS 106_ HTLKE 111_ QTNSG 116_ NLGKQ 121_ SEKGK 126_ QHKRR 131_ SWSIS 136_ LPSNN 141_ CTKNV 146_ SPLSK 151_ KLQDS 156_ LKALN 161_ LHSLY 166_ RARWT 171_ IEHTI 176_ CNSQT 181_ LEDIW 186_ TKLNQ 191_ IIRHN 196_ ELPSC 201_ NATIQ 206_ RHLGQ 211_ IWVFC 216_ DIMYC 221_ EYVGS 226_ LLKGR 231_ LALTG 236_ KINLF 241_VHKYG
1: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres