WD repeat- and FYVE domain-containing protein 4
1_MEAED 6_ LSKAE 11_ DRNED 16_ PGSKN 21_ EGQLA 26_ AVQPD 31_ VPHGG 36_ QSSSP 41_ TALWD 46_ MLERK 51_ FLEYQ 56_ QLTHK 61_ SPIER 66_ QKSLL 71_ SLLPL 76_ FLKAW 81_ EHSVG 86_ IICFP 91_ SLQRL 96_ AEDVS 101_ DQLAQ 106_ QLQKA 111_ LVGKP 116_ AEQAR 121_ LAAGQ 126_ LLWWK 131_ GDVDQ 136_ DGYLL 141_ LKSVY 146_ VLTGT 151_ DSETL 156_ GRVAE 161_ SGLPA 166_ LLLQC 171_ LYLFF 176_ VFPLD 181_ KDELL 186_ ESDLQ 191_ VQKMF 196_ VQMLL 201_ NICSD 206_ SQGLE 211_ GLLSG 216_ SELQS 221_ LLIAT 226_ TCLRE 231_ HSCCF 236_ WKEPT 241_ FCVLR 246_ AISKA 251_ QNLSI 256_ IQYLQ 261_ ATDCV 266_ RLSLQ 271_ NLSRL 276_ TDTLP 281_ APEVS 286_ EAVSL 291_ ILGFV 296_ KDSYP 301_ VSSAL 306_ FLEFE 311_ NSEGY 316_ PLLLK 321_ VLLRY 326_ DGLTQ 331_ SEVDP 336_ HLEEL 341_ LGLVV 346_ WLTTC 351_ GRSEL 356_ KVFDS 361_ ITYPQ 366_ LEGFK 371_ FHHEA 376_ SGVTV 381_ KNLQA 386_ FQVLQ 391_ NVFHK 396_ ASDSV 401_ LCIQV 406_ LSVIR 411_ TMWAW 416_ NARNF 421_ FLLEW 426_ TLQPI 431_ SQFVE 436_ IMPLK 441_ PAPVQ 446_ EHFFQ 451_ LLEAL 456_ VFELH 461_ YVPHE 466_ ILRKV 471_ QHLIK 476_ ESPGP 481_ SCTLM 486_ ALQSI 491_ LSIAG 496_ GDPLF 501_ TDIFR 506_ DSGLL 511_ GLLLA 516_ QLRKQ 521_ AKIMR 526_ KSGNK 531_ VSTPG 536_ VQDPE 541_ RELTC 546_ VMLRI 551_ VVTLL 556_ KGSVR 561_ NAVVL 566_ KDHGM 571_ VPFIK 576_ IFLDD 581_ ECYRE 586_ ASLSI 591_ LEQLS 596_ AINAE 601_ EYMSI 606_ IVGAL 611_ CSSTQ 616_ GELQL 621_ KLDLL 626_ KSLLR 631_ ILVTP 636_ KGRAA 641_ FRVSS 646_ GFNGL 651_ LSLLS 656_ DLEGS 661_ LQEPP 666_ LQAWG 671_ AVSPR 676_ QTLEL 681_ VLYTL 686_ CAVSA 691_ ALHWD 696_ PVNGY 701_ FFRRN 706_ GLFEK 711_ LAEDL 716_ CLLGC 721_ FGALE 726_ EEGNL 731_ LRSWV 736_ DTKAR 741_ PFADL 746_ LGTAF 751_ SSSGS 756_ LPPRI 761_ QSCLQ 766_ ILGFL 771_ DSMAS 776_ GTLHL 781_ RGDLK 786_ ESLRT 791_ KQGPV 796_ VDVQK 801_ GETGS 806_ DPQRN 811_ FKQWP 816_ DLEER 821_ MDEGD 826_ AAIMH 831_ PGVVC 836_ IMVRL 841_ LPRLY 846_ HEDHP 851_ QLSEE 856_ IQCSL 861_ ASHIQ 866_ SLVKS 871_ EKNRQ 876_ VMCEA 881_ GLLGT 886_ LMASC 891_ HRALV 896_ TSGSP 901_ LHSRL 906_ IRIFE 911_ KLASQ 916_ AIEPD 921_ VLRQF 926_ LGLGI 931_ PSSLS 936_ ATTKI 941_ LDSSH 946_ THRGN 951_ PGCSG 956_ SQTAQ 961_ GLAEG 966_ PWPAA 971_ PDAGL 976_ HPGVT 981_ QAPQP 986_ LGESQ 991_ DSTTA 996_ LQTAL 1001_ SLISM 1006_ TSPRN 1011_ LQPQR 1016_ AALAP 1021_ SFVEF 1026_ DMSVE 1031_ GYGCL 1036_ FIPTL 1041_ STVMG 1046_ TSTEY 1051_ SVSGG 1056_ IGTGA 1061_ TRPFP 1066_ PPGGL 1071_ TFSCW 1076_ FLISR 1081_ HGAAT 1086_ EGHPL 1091_ RFLTL 1096_ VRHLA 1101_ RTEQP 1106_ FVCFS 1111_ VSLCP 1116_ DDLSL 1121_ VVSTE 1126_ EKEFQ 1131_ PLDVM 1136_ EPEDD 1141_ SEPSA 1146_ GCQLQ 1151_ VRCGQ 1156_ LLACG 1161_ QWHHL 1166_ AVVVT 1171_ KEMKR 1176_ HCTVS 1181_ TCLDG 1186_ QVIGS 1191_ AKMLY 1196_ IQALP 1201_ GPFLS 1206_ MDPSA 1211_ FVDVY 1216_ GYIAT 1221_ PRVWK 1226_ QKSSL 1231_ IWRLG 1236_ PTYLF 1241_ EEAIS 1246_ METLE 1251_ VINKL 1256_ GPRYC 1261_ GNFQA 1266_ VHVQG 1271_ EDLDS 1276_ EATPF 1281_ VAEER 1286_ VSFGL 1291_ HIASS 1296_ SITSV 1301_ ADIRN 1306_ AYNEV 1311_ DSRLI 1316_ AKEMN 1321_ ISSRD 1326_ NAMPV 1331_ FLLRN 1336_ CAGHL 1341_ SGSLR 1346_ TIGAV 1351_ AVGQL 1356_ GVRVF 1361_ HSSPA 1366_ ASSLD 1371_ FIGGP 1376_ AILLG 1381_ LISLA 1386_ TDDHT 1391_ MYAAV 1396_ KVLHS 1401_ VLTSN 1406_ AMCDF 1411_ LMQHI 1416_ CGYQI 1421_ MAFLL 1426_ RKKAS 1431_ LLNHR 1436_ IFQLI 1441_ LSVAG 1446_ TVELG 1451_ FRSSA 1456_ ITNTG 1461_ VFQHI 1466_ LCNFE 1471_ LWMNT 1476_ ADNLE 1481_ LSLFS 1486_ HLLEI 1491_ LQSPR 1496_ EGPRN 1501_ AEAAH 1506_ QAQLI 1511_ PKLIF 1516_ LFNEP 1521_ SLIPS 1526_ KISTI 1531_ IGILA 1536_ CQLRG 1541_ HFSTQ 1546_ DLLRI 1551_ GLFVV 1556_ YTLKP 1561_ SSVNE 1566_ RQICM 1571_ DGALD 1576_ PSLPA 1581_ GSQTS 1586_ GKTIW 1591_ LRNQL 1596_ LEMLL 1601_ SVISS 1606_ PQLHL 1611_ SSESK 1616_ EEMFL 1621_ KLGPD 1626_ WFLLL 1631_ LQGHL 1636_ HASTT 1641_ VLALK 1646_ LLLYF 1651_ LASPS 1656_ LRTRF 1661_ RDGLC 1666_ AGSWV 1671_ ERSTE 1676_ GVDIV 1681_ MDNLK 1686_ SQSPL 1691_ PEQSP 1696_ CLLPG 1701_ FRVLN 1706_ DFLAH 1711_ HVHIP 1716_ EVYLI 1721_ VSTFF 1726_ LQTPL 1731_ TELMD 1736_ GPKDS 1741_ LDAML 1746_ QWLLQ 1751_ RHHQE 1756_ EVLQA 1761_ GLCTE 1766_ GALLL 1771_ LEMLK 1776_ ATMSQ 1781_ PLAGS 1786_ EDGAW 1791_ AQTFP 1796_ ASVLQ 1801_ FLSLV 1806_ HRTYP 1811_ QDPAW 1816_ RAPEF 1821_ LQTLA 1826_ IAAFP 1831_ LGAQK 1836_ GVGAE 1841_ STRNT 1846_ SSPEA 1851_ AAEGD 1856_ STVEG 1861_ LQAPT 1866_ KAHPA 1871_ RRKLR 1876_ EFTQL 1881_ LLREL 1886_ LLGAS 1891_ SPKQW 1896_ LPLEV 1901_ LLEAS 1906_ PDHAT 1911_ SQQKR 1916_ DFQSE 1921_ VLLSA 1926_ MELFH 1931_ MTSGG 1936_ DAAMF 1941_ RDGKE 1946_ PQPSA 1951_ EAAAA 1956_ PSLAN 1961_ ISCFT 1966_ QKLVE 1971_ KLYSG 1976_ MFSAD 1981_ PRHIL 1986_ LFILE 1991_ HIMVV 1996_ IETAS 2001_ SQRDT 2006_ VLSTL 2011_ YSSLN 2016_ KVILY 2021_ CLSKP 2026_ QQSLS 2031_ ECLGL 2036_ LSILG 2041_ FLQEH 2046_ WDVVF 2051_ ATYNS 2056_ NISFL 2061_ LCLMH 2066_ CLLLL 2071_ NERSY 2076_ PEGFG 2081_ LEPKP 2086_ RMSTY 2091_ HQVFL 2096_ SPNED 2101_ VKEKR 2106_ EDLPS 2111_ LSDVQ 2116_ HNIQK 2121_ TVQTL 2126_ WQQLV 2131_ AQRQQ 2136_ TLEDA 2141_ FKIDL 2146_ SVKPG 2151_ EREVK 2156_ IEEVT 2161_ PLWEE 2166_ TMLKA 2171_ WQHYL 2176_ ASEKK 2181_ SLASR 2186_ SNVAH 2191_ HSKVT 2196_ LWSGS 2201_ LSSAM 2206_ KLMPG 2211_ RQAKD 2216_ PECKT 2221_ EDFVS 2226_ CIENY 2231_ RRRGQ 2236_ ELYAS 2241_ LYKDH 2246_ VQRRK 2251_ CGNIK 2256_ AANAW 2261_ ARIQE 2266_ QLFGE 2271_ LGLWS 2276_ QGEET 2281_ KPCSP 2286_ WELDW 2291_ REGPA 2296_ RMRKR 2301_ IKRLS 2306_ PLEAL 2311_ SSGRH 2316_ KESQD 2321_ KNDHI 2326_ SQTNA 2331_ ENQDE 2336_ LTLRE 2341_ AEGEP 2346_ DEVGV 2351_ DCTQL 2356_ TFFPA 2361_ LHESL 2366_ HSEDF 2371_ LELCR 2376_ ERQVI 2381_ LQELL 2386_ DKEKV 2391_ TQKFS 2396_ LVIVQ 2401_ GHLVS 2406_ EGVLL 2411_ FGHQH 2416_ FYICE 2421_ NFTLS 2426_ PTGDV 2431_ YCTRH 2436_ CLSNI 2441_ SDPFI 2446_ FNLCS 2451_ KDRST 2456_ DHYSC 2461_ QCHSY 2466_ ADMRE 2471_ LRQAR 2476_ FLLQD 2481_ IALEI 2486_ FFHNG 2491_ YSKFL 2496_ VFYNN 2501_ DRSKA 2506_ FKSFC 2511_ SFQPS 2516_ LKGKA 2521_ TSEDT 2526_ LSLRR 2531_ YPGSD 2536_ RIMLQ 2541_ KWQKR 2546_ DISNF 2551_ EYLMY 2556_ LNTAA 2561_ GRTCN 2566_ DYMQY 2571_ PVFPW 2576_ VLADY 2581_ TSETL 2586_ NLANP 2591_ KIFRD 2596_ LSKPM 2601_ GAQTK 2606_ ERKLK 2611_ FIQRF 2616_ KEVEK 2621_ TEGDM 2626_ TVQCH 2631_ YYTHY 2636_ SSAII 2641_ VASYL 2646_ VRMPP 2651_ FTQAF 2656_ CALQG 2661_ GSFDV 2666_ ADRMF 2671_ HSVKS 2676_ TWESA 2681_ SRENM 2686_ SDVRE 2691_ LTPEF 2696_ FYLPE 2701_ FLTNC 2706_ NGVEF 2711_ GCMQD 2716_ GTVLG 2721_ DVQLP 2726_ PWADG 2731_ DPRKF 2736_ ISLHR 2741_ KALES 2746_ DFVSA 2751_ NLHHW 2756_ IDLIF 2761_ GYKQQ 2766_ GPAAV 2771_ DAVNI 2776_ FHPYF 2781_ YGDRM 2786_ DLSSI 2791_ TDPLI 2796_ KSTIL 2801_ GFVSN 2806_ FGQVP 2811_ KQLFT 2816_ KPHPA 2821_ RTAAG 2826_ KPLPG 2831_ KDVST 2836_ PVSLP 2841_ GHPQP 2846_ FFYSL 2851_ QSLRP 2856_ SQVTV 2861_ KDMYL 2866_ FSLGS 2871_ ESPKG 2876_ AIGHI 2881_ VSTEK 2886_ TILAV 2891_ ERNKV 2896_ LLPPL 2901_ WNRTF 2906_ SWGFD 2911_ DFSCC 2916_ LGSYG 2921_ SDKVL 2926_ MTFEN 2931_ LAAWG 2936_ RCLCA 2941_ VCPSP 2946_ TTIVT 2951_ SGTST 2956_ VVCVW 2961_ ELSMT 2966_ KGRPR 2971_ GLRLR 2976_ QALYG 2981_ HTQAV 2986_ TCLAA 2991_ SVTFS 2996_ LLVSG 3001_ SQDCT 3006_ CILWD 3011_ LDHLT 3016_ HVTRL 3021_ PAHRE 3026_ GISAI 3031_ TISDV 3036_ SGTIV 3041_ SCAGA 3046_ HLSLW 3051_ NVNGQ 3056_ PLASI 3061_ TTAWG 3066_ PEGAI 3071_ TCCCL 3076_ MEGPA 3081_ WDTSQ 3086_ IIITG 3091_ SQDGM 3096_ VRVWK 3101_ TEDVK 3106_ MSVPG 3111_ RPAGE 3116_ EPPAQ 3121_ PPSPR 3126_ GHKWE 3131_ KNLAL 3136_ SRELD 3141_ VSIAL 3146_ TGKPS 3151_ KTSPA 3156_ VTALA 3161_ VSRNH 3166_ TKLLV 3171_ GDERG 3176_RIFCW
1: Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy