Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509)
1_MDPVA 6_ THSCH 11_ LLQQL 16_ HEQRI 21_ QGLLC 26_ DCMLV 31_ VKGVC 36_ FKAHK 41_ NVLAA 46_ FSQYF 51_ RSLFQ 56_ NSSSQ 61_ KNDVF 66_ HLDVK 71_ NVSGI 76_ GQILD 81_ FMYTS 86_ HLDLN 91_ QDNIQ 96_ VMLDT 101_ AQCLQ 106_ VQNVL 111_ SLCHT 116_ FLKSA 121_ TVVQP 126_ PGMPC 131_ NSTLS 136_ LQSTL 141_ TPDAT 146_ CVISE 151_ NYPPH 156_ LLQEC 161_ SADAQ 166_ QNKTL 171_ DESHP 176_ HASPS 181_ VNRHH 186_ SAGEI 191_ SKQAP 196_ DTSDG 201_ SCTEL 206_ PFKQP 211_ NYYYK 216_ LRNFY 221_ SKQYH 226_ KHAAG 231_ PSQER 236_ VVEQP 241_ FAFST 246_ STDLT 251_ TVESQ 256_ PCAVS 261_ HSECI 266_ LESPE 271_ HLPSN 276_ FLAQP 281_ VNDSA 286_ PHPES 291_ DATCQ 296_ QPVKQ 301_ MRLKK 306_ AIHLK 311_ KLNFL 316_ KSQKY 321_ AEQVS 326_ EPKSD 331_ DGLTK 336_ RLESA 341_ SKNTL 346_ EKASS 351_ QSAEE 356_ KESEE 361_ VVSCE 366_ NFNCI 371_ SETER 376_ PEDPA 381_ ALEDQ 386_ SQTLQ 391_ SQRQY 396_ ACELC 401_ GKPFK 406_ HPSNL 411_ ELHKR 416_ SHTGE 421_ KPFEC 426_ NICGK 431_ HFSQA 436_ GNLQT 441_ HLRRH 446_ SGEKP 451_ YICEI 456_ CGKRF 461_ AASGD 466_ VQRHI 471_ IIHSG 476_ EKPHL 481_ CDICG 486_ RGFSN 491_ FSNLK 496_ EHKKT 501_ HTADK 506_ VFTCD 511_ ECGKS 516_ FNMQR 521_ KLVKH 526_ RIRHT 531_ GERPY 536_ SCSAC 541_ GKCFG 546_ GSGDL 551_ RRHVR 556_ THTGE 561_ KPYTC 566_ EICNK 571_ CFTRS 576_ AVLRR 581_ HKKMH 586_ CKAGD 591_ ESPDV 596_ LEELS 601_ QAIET 606_ SDLEK 611_ SQSSD 616_ SFSQD 621_ TSVTL 626_ MPVSV 631_ KLPVH 636_ PVENS 641_ VAEFD 646_ SHSGG 651_ SYCKL 656_ RSMIQ 661_ PHGVS 666_ DQEKL 671_ SLDPG 676_ KLAKP 681_ QMQQT 686_ QPQAY 691_ AYSDV 696_ DTPAG 701_ GEPLQ 706_ ADGMA 711_ MIRSS 716_ LAALD 721_ NHGGD 726_ PLGSR 731_ ASSTT 736_ YRNSE 741_ GQFFS 746_ SMTLW 751_ GLAMK 756_TLQNE
1: Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription
2: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive)
3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter