E3 ubiquitin-protein ligase RNF165 (EC 2.3.2.27) (RING finger protein 165)
1_MVLVH 6_ VGYLV 11_ LPVFG 16_ SVRNR 21_ GAPFQ 26_ RSQHP 31_ HATSC 36_ RHFHL 41_ GPPQP 46_ QQLAP 51_ DFPLA 56_ HPVQS 61_ QPGLS 66_ AHMAP 71_ AHQHS 76_ GALHQ 81_ SLTPL 86_ PTLQF 91_ QDVTG 96_ PSFLP 101_ QALHQ 106_ QYLLQ 111_ QQLLE 116_ AQHRR 121_ LVSHP 126_ RRSQE 131_ RVSVH 136_ PHRLH 141_ PSFDF 146_ GQLQT 151_ PQPRY 156_ LAEGT 161_ DWDLS 166_ VDAGL 171_ SPAQF 176_ QVRPI 181_ PQHYQ 186_ HYLAT 191_ PRMHH 196_ FPRNS 201_ SSTQM 206_ VVHEI 211_ RNYPY 216_ PQLHF 221_ LALQG 226_ LNPSR 231_ HTSAV 236_ RESYE 241_ ELLQL 246_ EDRLG 251_ NVTRG 256_ AVQNT 261_ IERFT 266_ FPHKY 271_ KKRRP 276_ QDGKG 281_ KKDEG 286_ EESDT 291_ DEKCT 296_ ICLSM 301_ LEDGE 306_ DVRRL 311_ PCMHL 316_ FHQLC 321_ VDQWL 326_ AMSKK 331_ CPICR 336_ VDIET 341_QLGAD
1: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL