Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
1_MGDDQ 6_ EDDFP 11_ RRLSE 16_ SMEDL 21_ SLDLG 26_ ALQGS 31_ EYLQD 36_ LGLGA 41_ PSHSQ 46_ PGETP 51_ DSRPT 56_ GEEPG 61_ RDSLF 66_ SSLAG 71_ SQDLS 76_ RRRSW 81_ ERSRS 86_ CSESW 91_ RRLSL 96_ DASAV 101_ DEEPC 106_ LPRTL 111_ ASLAL 116_ NLPGG 121_ GLKTW 126_ TQGCL 131_ SGGGT 136_ PAESP 141_ GKECD 146_ SPKKR 151_ GRSRS 156_ VPVSF 161_ YEIRS 166_ PEISP 171_ GLEVP 176_ TPPVQ 181_ GLEPP 186_ VLECM 191_ EKDHV 196_ EPDHV 201_ LIVQQ 206_ VLQEL 211_ RQYHG 216_ ARQRA 221_ CMSAS 226_ PGGAH 231_ SNLTW 236_ FEFLS 241_ ESEDG 246_ AGKNE 251_ KSDKS 256_ TSVKR 261_ RLSCL 266_ RSRVT 271_ RQKEK 276_ GKSPA 281_ HLKDK 286_ GQDAR 291_ ERREC 296_ VNGHQ 301_ LLQGT 306_ FSGPS 311_ SCPLC 316_ GKPFL 321_ SSASL 326_ KEHPR 331_ GTLLS 336_ DGSPA 341_ LSRNV 346_ GMTVS 351_ QKGGP 356_ QPTPS 361_ PAGPG 366_ TQLGP 371_ ITGEM 376_ DEADS 381_ AFLKF 386_ KQTAD 391_ DSLSL 396_ TSPNT 401_ ESIFV 406_ EDPYT 411_ ASLRS 416_ EIESD 421_ GHEFE 426_ AESWS 431_ LAVDA 436_ AYAKK 441_ QKREV 446_ VKRQD 451_ VLYEL 456_ MQTEV 461_ HHVRT 466_ LKIML 471_ KVYSR 476_ ALQEE 481_ LQFSS 486_ KAIGR 491_ LFPCA 496_ DDLLE 501_ THSHF 506_ LARLK 511_ ERRQE 516_ SLEEG 521_ SDRNY 526_ VIQKI 531_ GDLLV 536_ QQFSG 541_ ENGER 546_ MKEKY 551_ GVFCS 556_ GHNEA 561_ VSHYK 566_ LLLQQ 571_ NKKFQ 576_ NLIKK 581_ IGNFS 586_ IVRRL 591_ GVQEC 596_ ILLVT 601_ QRITK 606_ YPVLV 611_ ERIIQ 616_ NTEAG 621_ TEDYE 626_ DLTQA 631_ LNLIK 636_ DIISQ 641_ VDAKV 646_ SECEK 651_ GQRLR 656_ EIAGK 661_ MDLKS 666_ SSKLK 671_ NGLTF 676_ RKEDM 681_ LQRQL 686_ HLEGM 691_ LCWKT 696_ TSGRL 701_ KDILA 706_ ILLTD 711_ VLLLL 716_ QEKDQ 721_ KYVFA 726_ SVDSK 731_ PPVIS 736_ LQKLI 741_ VREVA 746_ NEEKA 751_ MFLIS 756_ ASLQG 761_ PEMYE 766_ IYTSS 771_ KEDRN 776_ AWMAH 781_ IQRAV 786_ ESCPD 791_ EEEGP 796_ FSLPE 801_ EERKV 806_ VEARA 811_ TRLRD 816_ FQERL 821_ SMKDQ 826_ LIAQS 831_ LLEKQ 836_ QIYLE 841_ MAEMG 846_ GLEDL 851_ PQPRG 856_ LFRGG 861_ DPSET 866_ LQGEL 871_ ILKSA 876_ MSEIE 881_ GIQSL 886_ ICRQL 891_ GSANG 896_ QAEDG 901_ GSSTG 906_ PPRRA 911_ ETFAG 916_ YDCTN 921_ SPTKN 926_ GSFKK 931_ KVSST 936_ DPRPR 941_ DWRGP 946_ PNSPD 951_ LKLSD 956_ SDIPG 961_ SSEES 966_ PQVVE 971_ APGTE 976_ SDPRL 981_ PTVLE 986_ SELVQ 991_ RIQTL 996_ SQLLL 1001_ NLQAV 1006_ IAHQD 1011_ SYVET 1016_ QRAAI 1021_ QEREK 1026_ QFRLQ 1031_ STRGN 1036_ LLLEQ 1041_ ERQRN 1046_ FEKQR 1051_ EERAA 1056_ LEKLQ 1061_ SQLRH 1066_ EQQRW 1071_ ERERQ 1076_ WQHQE 1081_ LERAG 1086_ ARLQE 1091_ REGEA 1096_ RQLRE 1101_ RLEQE 1106_ RAELE 1111_ RQRQA 1116_ YQHDL 1121_ ERLRE 1126_ AQRAV 1131_ ERERE 1136_ RLELL 1141_ RRLKK 1146_ QNTAP 1151_ GALPP 1156_ DTLAE 1161_ AQPPS 1166_ HPPSF 1171_ NGEGL 1176_ EGPRV 1181_ SMLPS 1186_ GVGPE 1191_ YAERP 1196_ EVARR 1201_ DSAPT 1206_ ENRLA 1211_ KSDVP 1216_ IQLLS 1221_ ATNQF 1226_ QRQAA 1231_ VQQQI 1236_ PTKLA 1241_ ASTKG 1246_ GKDKG 1251_ GKSRG 1256_ SQRWE 1261_ SSASF 1266_ DLKQQ 1271_ LLLNK 1276_ LMGKD 1281_ ESTSR 1286_ NRRSL 1291_ SPILP 1296_ GRHSP 1301_ APPPD 1306_ PGFPA 1311_ PSPPP 1316_ ADSPS 1321_ EGFSL 1326_ KAGGT 1331_ ALLPG 1336_ PPAPS 1341_ PLPAT 1346_ PLSAK 1351_ EDASK 1356_EDVIF
1: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950)