E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)
1_MAAAA 6_ AAAVG 11_ GQQPS 16_ QPELP 21_ APGLA 26_ LDKAA 31_ TAAHL 36_ KAALS 41_ RPDNR 46_ AGAEE 51_ LQALL 56_ ERVLS 61_ AERPL 66_ AAAAG 71_ GEDAA 76_ AAGGG 81_ GGPGA 86_ AEEEA 91_ LEWCK 96_ CLLAG 101_ GGGYD 106_ EFCAA 111_ VRAYD 116_ PAALC 121_ GLVWT 126_ ANFVA 131_ YRCRT 136_ CGISP 141_ CMSLC 146_ AECFH 151_ QGDHT 156_ GHDFN 161_ MFRSQ 166_ AGGAC 171_ DCGDS 176_ NVMRE 181_ SGFCK 186_ RHQIK 191_ SSSNI 196_ PCVPK 201_ DLLMM 206_ SEFVL 211_ PRFIF 216_ CLIQY 221_ LREGY 226_ NEPAA 231_ DGPSE 236_ KDLNK 241_ VLQLL 246_ EPQIS 251_ FLEDL 256_ TKMGG 261_ AMRSV 266_ LTQVL 271_ TNQQN 276_ YKDLT 281_ SGLGE 286_ NACVK 291_ KSHEK 296_ YLIAL 301_ KSSGL 306_ TYPED 311_ KLVYG 316_ VQEPS 321_ AGTSS 326_ LAVQG 331_ FIGAT 336_ GTLGQ 341_ VDSSD 346_ EDDQD 351_ GSQGL 356_ GKRKR 361_ VKLSS 366_ GTKDQ 371_ SIMDV 376_ LKHKS 381_ FLEEL 386_ LFWTI 391_ KYEFP 396_ QKMVT 401_ FLLNM 406_ LPDQE 411_ YKVAF 416_ TKTFV 421_ QHYAF 426_ IMKTL 431_ KKSHE 436_ SDTMS 441_ NRIVH 446_ ISVQL 451_ FSNEE 456_ LARQV 461_ TEECQ 466_ LLDIM 471_ VTVLL 476_ YMMES 481_ CLIKS 486_ ELQDE 491_ ENSLH 496_ VVVNC 501_ GEALL 506_ KNNTY 511_ WPLVS 516_ DFINI 521_ LSHQS 526_ VAKRF 531_ LEDHG 536_ LLVTW 541_ MNFVS 546_ FFQGM 551_ NLNKR 556_ ELNEH 561_ VEFES 566_ QTYYA 571_ AFAAE 576_ LEACA 581_ QPMWG 586_ LLSHC 591_ KVRET 596_ QEYTR 601_ NVVRY 606_ CLEAL 611_ QDWFD 616_ AINFV 621_ DEPAP 626_ NQVTF 631_ HLPLH 636_ RYYAM 641_ FLSKA 646_ VKCQE 651_ LDLDS 656_ VLPDQ 661_ EMLMK 666_ LMIHP 671_ LQIQA 676_ SLAEI 681_ HSNMW 686_ VRNGL 691_ QIKGQ 696_ AMTYV 701_ QSHFC 706_ NSMID 711_ PDIYL 716_ LQVCA 721_ SRLDP 726_ DYFIS 731_ SVFER 736_ FKVVD 741_ LLTMA 746_ SQHQN 751_ TVLDA 756_ EHERS 761_ MLEGA 766_ LTFLV 771_ ILLSL 776_ RLHLG 781_ MSDDE 786_ ILRAE 791_ MVAQL 796_ CMNDR 801_ THSSL 806_ LDLIP 811_ ENPNP 816_ KSGII 821_ PGSYS 826_ FESVL 831_ SAVAD 836_ FKAPV 841_ FEPGG 846_ SMQQG 851_ MYTPK 856_ AEVWD 861_ QEFDP 866_ VMVIL 871_ RTVYR 876_ RDVQS 881_ AMDRY 886_ TAFLK 891_ QSGKF 896_ PGNPW 901_ PPYKK 906_ RTSLH 911_ PSYKG 916_ LMRLL 921_ HCKTL 926_ HIVLF 931_ TLLYK 936_ ILMDH 941_ QNLSE 946_ HVLCM 951_ VLYLI 956_ ELGLE 961_ NSAEE 966_ ESDEE 971_ ASVGG 976_ PERCH 981_ DSWFP 986_ GSNLV 991_ SNMRH 996_ FINYV 1001_ RVRVP 1006_ ETAPE 1011_ VKRDS 1016_ PASTS 1021_ SDNLG 1026_ SLQNS 1031_ GTAQV 1036_ FSLVA 1041_ ERRKK 1046_ FQEII 1051_ NRSSS 1056_ EANQV 1061_ VRPKT 1066_ SSKWS 1071_ APGSA 1076_ PQLTT 1081_ AILEI 1086_ KESIL 1091_ SLLIK 1096_ LHHKL 1101_ SGKQN 1106_ SYYPP 1111_ WLDDI 1116_ EILIQ 1121_ PEIPK 1126_ YSHGD 1131_ GITAV 1136_ ERILL 1141_ KAASQ 1146_ SRMNK 1151_ RIIEE 1156_ ICRKV 1161_ TPPVP 1166_ PKKVT 1171_ AAEKK 1176_ TLDKE 1181_ ERRQK 1186_ ARERQ 1191_ QKLLA 1196_ EFASR 1201_ QKSFM 1206_ ETAMD 1211_ VDSPE 1216_ NDIPM 1221_ EITTA 1226_ EPQVS 1231_ EAVYD 1236_ CVICG 1241_ QSGPS 1246_ SEDRP 1251_ TGLVV 1256_ LLQAS 1261_ SVLGQ 1266_ CRDNV 1271_ EPKKL 1276_ PISEE 1281_ EQIYP 1286_ WDTCA 1291_ AVHDV 1296_ RLSLL 1301_ QRYFK 1306_ DSSCL 1311_ LAVSI 1316_ GWEGG 1321_ VYVQT 1326_ CGHTL 1331_ HIDCH 1336_ KSYME 1341_ SLRND 1346_ QVLQG 1351_ FSVDK 1356_ GEFTC 1361_ PLCRQ 1366_ FANSV 1371_ LPCYP 1376_ GSNVE 1381_ NNPWQ 1386_ RPSNK 1391_ SIQDL 1396_ IKEVE 1401_ ELQGR 1406_ PGAFP 1411_ SETNL 1416_ SKEME 1421_ SVMKD 1426_ IKNTT 1431_ QKKYR 1436_ DYSKT 1441_ PGSPD 1446_ NDFLF 1451_ MYSVA 1456_ RTNLE 1461_ LELIH 1466_ RGGNL 1471_ CSGGA 1476_ STAGK 1481_ RSCLN 1486_ QLFHV 1491_ LALHM 1496_ RLYSI 1501_ DSEYN 1506_ PWRKL 1511_ TQLEE 1516_ MNPQL 1521_ GYEEQ 1526_ QPEVP 1531_ ILYHD 1536_ VTSLL 1541_ LIQIL 1546_ MMPQP 1551_ LRKDH 1556_ FTCIV 1561_ KVLFT 1566_ LLYTQ 1571_ ALAAL 1576_ SVKCS 1581_ EEDRS 1586_ AWKHA 1591_ GALKK 1596_ STCDA 1601_ EKSYE 1606_ VLLSF 1611_ VISEL 1616_ FKGKL 1621_ YHEEG 1626_ TQECA 1631_ MVNPI 1636_ AWSPE 1641_ SMEKC 1646_ LQDFC 1651_ LPFLR 1656_ ITSLL 1661_ QHHLF 1666_ GEDLP 1671_ SCQEE 1676_ EEFSV 1681_ LASCL 1686_ GLLPT 1691_ FYQTE 1696_ HPFIS 1701_ ASCLD 1706_ WPVPA 1711_ FDIIT 1716_ QWCFE 1721_ IKSFT 1726_ ERHAE 1731_ QGKAL 1736_ LIQES 1741_ KWKLP 1746_ HLLQL 1751_ PENYN 1756_ TIFQY 1761_ YHRKT 1766_ CSVCT 1771_ KVPKD 1776_ PAVCL 1781_ VCGTF 1786_ VCLKG 1791_ LCCKQ 1796_ QSYCE 1801_ CVLHS 1806_ QNCGA 1811_ GTGIF 1816_ LLINA 1821_ SVIII 1826_ IRGHR 1831_ FCLWG 1836_ SVYLD 1841_ AHGEE 1846_ DRDLR 1851_ RGKPL 1856_ YICKE 1861_ RYKVL 1866_ EQQWI 1871_ SHTFD 1876_ HINKR 1881_WGPHY
1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610)