Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)
1_MPSLP 6_ QEGVI 11_ QGPSP 16_ LDLNT 21_ ELPYQ 26_ STMKR 31_ KVRKK 36_ KKKGT 41_ ITANV 46_ AGTKF 51_ EIVRL 56_ VIDEM 61_ GFMKT 66_ PDEDE 71_ TSNLI 76_ WCDSA 81_ VQQEK 86_ ISELQ 91_ NYQRI 96_ NHFPG 101_ MGEIC 106_ RKDFL 111_ ARNMT 116_ KMIKS 121_ RPLDY 126_ TFVPR 131_ TWIFP 136_ AEYTQ 141_ FQNYV 146_ KELKK 151_ KRKQK 156_ TFIVK 161_ PANGA 166_ MGHGI 171_ SLIRN 176_ GDKLP 181_ SQDHL 186_ IVQEY 191_ IEKPF 196_ LMEGY 201_ KFDLR 206_ IYILV 211_ TSCDP 216_ LKIFL 221_ YHDGL 226_ VRMGT 231_ EKYIP 236_ PNESN 241_ LTQLY 246_ MHLTN 251_ YSVNK 256_ HNEHF 261_ ERDET 266_ ENKGS 271_ KRSIK 276_ WFTEF 281_ LQANQ 286_ HDVAK 291_ FWSDI 296_ SELVV 301_ KTLIV 306_ AEPHV 311_ LHAYR 316_ MCRPG 321_ QPPGS 326_ ESVCF 331_ EVLGF 336_ DILLD 341_ RKLKP 346_ WLLEI 351_ NRAPS 356_ FGTDQ 361_ KIDYD 366_ VKRGV 371_ LLNAL 376_ KLLNI 381_ RTSDK 386_ RRNLA 391_ KQKAE 396_ AQRRL 401_ YGQNS 406_ IKRLL 411_ PGSSD 416_ WEQQR 421_ HQLER 426_ RKEEL 431_ KERLA 436_ QVRKQ 441_ ISREE 446_ HENRH 451_ MGNYR 456_ RIYPP 461_ EDKAL 466_ LEKYE 471_ NLLAV 476_ AFQTF 481_ LSGRA 486_ ASFQR 491_ ELNNP 496_ LKRMK 501_ EEDIL 506_ DLLEQ 511_ CEIDD 516_ EKLMG 521_ KTTKT 526_ RGPKP 531_ LCSMP 536_ ESTEI 541_ MKRPK 546_ YCSSD 551_ SSYDS 556_ SSSSS 561_ ESDEN 566_ EKEEY 571_ QNKKR 576_ EKQVT 581_ YNLKP 586_ SNHYK 591_ LIQQP 596_ SSIRR 601_ SVSCP 606_ RSISA 611_ QSPSS 616_ GDTRP 621_ FSAQQ 626_ MISVS 631_ RPTSA 636_ SRSHS 641_ LNRAS 646_ SYMRH 651_ LPHSN 656_ DACST 661_ NSQVS 666_ ESLRQ 671_ LKTKE 676_ QEDDL 681_ TSQTL 686_ FVLKD 691_ MKIRF 696_ PGKSD 701_ AESEL 706_ LIEDI 711_ IDNWK 716_ YHKTK 721_ VASYW 726_ LIKLD 731_ SVKQR 736_ KVLDI 741_ VKTSI 746_ RTVLP 751_ RIWKV 756_ PDVEE 761_ VNLYR 766_ IFNRV 771_ FNRLL 776_ WSRGQ 781_ GLWNC 786_ FCDSG 791_ SSWES 796_ IFNKS 801_ PEVVT 806_ PLQLQ 811_ CCQRL 816_ VELCK 821_ QCLLV 826_ VYKYA 831_ TDKRG 836_ SLSGI 841_ GPDWG 846_ NSRYL 851_ LPGST 856_ QFFLR 861_ TPTYN 866_ LKYNS 871_ PGMTR 876_ SNVLF 881_TSRYG
1: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:16901895, PubMed:25959773). Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction (PubMed:16901895, PubMed:25959773). Preferentially modifies the beta-tubulin tail over an alpha-tail (PubMed:16901895, PubMed:25959773). Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity)