Ankyrin repeat domain-containing protein 13D
1_MAGPG 6_ PTFPL 11_ HRLVW 16_ ANRHR 21_ ELEAA 26_ LHSHQ 31_ HDIEQ 36_ EDPRG 41_ RTPLE 46_ LAVSL 51_ GNLES 56_ VRVLL 61_ RHNAN 66_ VGKEN 71_ RQGWA 76_ VLQEA 81_ VSTGD 86_ PEMVQ 91_ LVLQY 96_ RDYQR 101_ ATQRL 106_ AGIPE 111_ LLNKL 116_ RQAPD 121_ FYVEM 126_ KWEFT 131_ SWVPL 136_ VSKMC 141_ PSDVY 146_ RVWKR 151_ GESLR 156_ VDTSL 161_ LGFEH 166_ MTWQR 171_ GRRSF 176_ IFKGQ 181_ EAGAL 186_ VMEVD 191_ HDRQV 196_ VHVET 201_ LGLTL 206_ QEPET 211_ LLAAM 216_ RPSEE 221_ HVASR 226_ LTSPI 231_ VSTHL 236_ DTRNV 241_ AFERN 246_ KCGIW 251_ GWRSE 256_ KMETV 261_ SGYEA 266_ KVYSA 271_ TNVEL 276_ VTRTR 281_ TEHLS 286_ DQDKS 291_ RSKAG 296_ KTPFQ 301_ SFLGM 306_ AQQHS 311_ SHTGA 316_ PVQQA 321_ ASPTN 326_ PTAIS 331_ PEEYF 336_ DPNFS 341_ LESRN 346_ IGRPI 351_ EMSSK 356_ VQRFK 361_ ATLWL 366_ SEEHP 371_ LSLGD 376_ QVTPI 381_ IDLMA 386_ ISNAH 391_ FAKLR 396_ DFITL 401_ RLPPG 406_ FPVKI 411_ EIPLF 416_ HVLNA 421_ RITFS 426_ NLCGC 431_ DEPLS 436_ SVWVP 441_ APSSA 446_ VAASG 451_ NPFPC 456_ EVDPT 461_ VFEVP 466_ NGYSV 471_ LGMER 476_ NEPLR 481_ DEDDD 486_ LLQFA 491_ IQQSL 496_ LEAGT 501_ EAEQV 506_ TVWEA 511_ LTNTR 516_ PGARP 521_ PPQAT 526_ VYEEQ 531_ LQLER 536_ ALQES 541_ LQLST 546_ EPRGP 551_ GSPPR 556_ TPPAP 561_ GPPSF 566_ EEQLR 571_ LALEL 576_ SSREQ 581_ EERER 586_ RGQQE 591_ EEDLQ 596_RILQL
1: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane