PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
1_MKRNG 6_ SRNCL 11_ NRRSR 16_ FGSRE 21_ RDWLR 26_ EDVKR 31_ GCVYL 36_ YGADT 41_ TTATT 46_ TTTTS 51_ SSSSS 56_ SSSSS 61_ DLHLV 66_ LCTVE 71_ TPASE 76_ ICAGE 81_ GRESL 86_ YLQLH 91_ GDLVR 96_ RLEPT 101_ ERPLQ 106_ IVYDY 111_ LSRLG 116_ FDDPV 121_ RIQEE 126_ ATNPD 131_ LGCMI 136_ RFYGE 141_ KPCHM 146_ DRLDR 151_ ILLSG 156_ IYNVR 161_ KGKTQ 166_ LHKWA 171_ ERLVV 176_ LCGTC 181_ LIVSS 186_ VKDCQ 191_ TGKMH 196_ ILPLV 201_ GGKIE 206_ EVKRR 211_ QYSLA 216_ FSSAG 221_ AQAQT 226_ YHVSF 231_ ETLAE 236_ YQRWQ 241_ RQASK 246_ VVSQR 251_ ISTVD 256_ LSCYS 261_ LEEVP 266_ EHLFY 271_ SQDIT 276_ YLNLR 281_ HNFMQ 286_ LERPG 291_ GLDTL 296_ YKFSQ 301_ LKGLN 306_ LSHNK 311_ LGLFP 316_ ILLCE 321_ ISTLT 326_ ELNLS 331_ CNGFH 336_ DLPSQ 341_ IGNLL 346_ NLQTL 351_ CLDGN 356_ FLTTL 361_ PEELG 366_ NLQQL 371_ SSLGI 376_ SFNNF 381_ SQIPE 386_ VYEKL 391_ TMLDR 396_ VVMAG 401_ NCLEV 406_ LNLGV 411_ LNRMN 416_ HIKHV 421_ DLRMN 426_ HLKTM 431_ VIENL 436_ EGNKH 441_ ITHVD 446_ LRDNR 451_ LTDLD 456_ LSSLC 461_ SLEQL 466_ HCGRN 471_ QLREL 476_ TLSGF 481_ SLRTL 486_ YASSN 491_ RLTAV 496_ NVYPV 501_ PSLLT 506_ FLDLS 511_ RNLLE 516_ CVPDW 521_ ACEAK 526_ KIEVL 531_ DVSYN 536_ LLTEV 541_ PVRIL 546_ SSLSL 551_ RKLML 556_ GHNHV 561_ QNLPT 566_ LVEHI 571_ PLEVL 576_ DLQHN 581_ ALTRL 586_ PDTLF 591_ SKALN 596_ LRYLN 601_ ASANS 606_ LESLP 611_ SACTG 616_ EESLS 621_ MLQLL 626_ YLTNN 631_ LLTDQ 636_ CIPVL 641_ VGHLH 646_ LRILH 651_ LANNQ 656_ LQTFP 661_ ASKLN 666_ KLEQL 671_ EELNL 676_ SGNKL 681_ KTIPT 686_ TIANC 691_ KRLHT 696_ LVAHS 701_ NNISI 706_ FPEIL 711_ QLPQI 716_ QFVDL 721_ SCNDL 726_ TEILI 731_ PEALP 736_ ATLQD 741_ LDLTG 746_ NTNLV 751_ LEHKT 756_ LDIFS 761_ HITTL 766_ KIDQK 771_ PLPTT 776_ DSTVT 781_ STFWS 786_ HGLAE 791_ MAGQR 796_ NKLCV 801_ SALAM 806_ DSFAE 811_ GVGAV 816_ YGMFD 821_ GDRNE 826_ ELPRL 831_ LQCTM 836_ ADVLL 841_ EEVQQ 846_ STNDT 851_ VFMAN 856_ TFLVS 861_ HRKLG 866_ MAGQK 871_ LGSSA 876_ LLCYI 881_ RPDTA 886_ DPASS 891_ FSLTV 896_ ANVGT 901_ CQAVL 906_ CRGGK 911_ PVPLS 916_ KVFSL 921_ EQDPE 926_ EAQRV 931_ KDQKA 936_ IITED 941_ NKVNG 946_ VTCCT 951_ RMLGC 956_ TYLYP 961_ WILPK 966_ PHISS 971_ TPLTI 976_ QDELL 981_ ILGNK 986_ ALWEH 991_ LSYTE 996_ AVNAV 1001_ RHVQD 1006_ PLAAA 1011_ KKLCT 1016_ LAQSY 1021_ GCQDN 1026_ VGAMV 1031_ VYLNI 1036_ GEEGC 1041_ TCEMN 1046_ GLTLP 1051_ GPVGF 1056_ ASTTT 1061_ IKDAP 1066_ KPATP 1071_ SSSSG 1076_ IASEF 1081_ SSEMS 1086_ TSEVS 1091_ SEVGS 1096_ TASDE 1101_ HNAGG 1106_ LDTAL 1111_ LPRPE 1116_ RRCSL 1121_ HPTPT 1126_ SGLFQ 1131_ RQPSS 1136_ ATFSS 1141_ NQSDN 1146_ GLDSD 1151_ DDQPV 1156_ EGVIT 1161_ NGSKV 1166_ EVEVD 1171_ IHCCR 1176_ GRDLE 1181_ NSPPL 1186_ IESSP 1191_ TLCSE 1196_ EHARG 1201_ SCFGI 1206_ RRQNS 1211_ VNSGM 1216_ LLPMS 1221_ KDRME 1226_ LQKSP 1231_ STSCL 1236_ YGKKL 1241_ SNGSI 1246_ VPLED 1251_ SLNLI 1256_ EVATE 1261_ VPKRK 1266_ TGYFA 1271_ APTQM 1276_ EPEDQ 1281_ FVVPH 1286_ DLEEE 1291_ VKEQM 1296_ KQHQD 1301_ SRLEP 1306_ EPHEE 1311_ DRTEP 1316_PEEFD
1: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606)