8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)
1_MASEG 6_ LAGAL 11_ ASVLA 16_ GQGSS 21_ VHSCD 26_ SAPAG 31_ EPPAP 36_ VRLRK 41_ NVCYV 46_ VLAVF 51_ LSEQD 56_ EVLLI 61_ QEAKR 66_ ECRGS 71_ WYLPA 76_ GRMEP 81_ GETIV 86_ EALQR 91_ EVKEE 96_ AGLHC 101_ EPETL 106_ LSVEE 111_ RGPSW 116_ VRFVF 121_ LARPT 126_ GGILK 131_ TSKEA 136_ DAESL 141_ QAAWY 146_ PRTSL 151_ PTPLR 156_ AHDIL 161_ HLVEL 166_ AAQYR 171_ QQARH 176_ PLILP 181_ QELPC 186_ DLVCQ 191_ RLVAT 196_ FTSAQ 201_ TVWVL 206_ VGTVG 211_ MPHLP 216_ VTACG 221_ LDPME 226_ QRGGM 231_ KMAVL 236_ RLLQE 241_ CLTLH 246_ HLVVE 251_ IKGLL 256_ GLQHL 261_ GRDHS 266_ DGICL 271_ NVLVT 276_ VAFRS 281_ PGIQD 286_ EPPKV 291_ RGENF 296_ SWWKV 301_ MEEDL 306_ QSQLL 311_ QRLQG 316_SSVVP
1: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools