Patched domain-containing protein 4 (p53-regulated patched protein)
1_MCFLR 6_ RPGAP 11_ ASWIW 16_ WRMLR 21_ QVLRR 26_ GLQSF 31_ CHRLG 36_ LCVSR 41_ HPVFF 46_ LTVPA 51_ VLTIT 56_ FGLSA 61_ LNRFQ 66_ PEGDL 71_ ERLVA 76_ PSHSL 81_ AKIER 86_ SLASS 91_ LFPLD 96_ QSKSQ 101_ LYSDL 106_ HTPGR 111_ YGRVI 116_ LLSPT 121_ GDNIL 126_ LQAEG 131_ ILQTH 136_ RAVLE 141_ MKDGR 146_ NSFIG 151_ HQLGG 156_ VVEVP 161_ NSKDQ 166_ RVKSA 171_ RAIQI 176_ TYYLQ 181_ TYGSA 186_ TQDLI 191_ GEKWE 196_ NEFCK 201_ LIRKL 206_ QEEHQ 211_ ELQLY 216_ SLASF 221_ SLWRD 226_ FHKTS 231_ ILARS 236_ KVLVS 241_ LVLIL 246_ TTATL 251_ SSSMK 256_ DCLRS 261_ KPFLG 266_ LLGVL 271_ TVCIS 276_ IITAA 281_ GIFFI 286_ TDGKY 291_ NSTLL 296_ GIPFF 301_ AMGHG 306_ TKGVF 311_ ELLSG 316_ WRRTK 321_ ENLPF 326_ KDRIA 331_ DAYSD 336_ VMVTY 341_ TMTSS 346_ LYFIT 351_ FGMGA 356_ SPFTN 361_ IEAVK 366_ VFCQN 371_ MCVSI 376_ LLNYF 381_ YIFSF 386_ FGSCL 391_ VFAGQ 396_ LEQNR 401_ YHSIF 406_ CCKIP 411_ SAEYL 416_ DRKPV 421_ WFQTV 426_ MSDGH 431_ QQTSH 436_ HETNP 441_ YQHHF 446_ IQHFL 451_ REHYN 456_ EWITN 461_ IYVKP 466_ FVVIL 471_ YLIYA 476_ SFSFM 481_ GCLQI 486_ SDGAN 491_ IINLL 496_ ASDSP 501_ SVSYA 506_ MVQQK 511_ YFSNY 516_ SPVIG 521_ FYVYE 526_ PLEYW 531_ NSSVQ 536_ DDLRR 541_ LCSGF 546_ TAVSW 551_ VEQYY 556_ QFLKV 561_ SNVSA 566_ NNKSD 571_ FISVL 576_ QSSFL 581_ KKPEF 586_ QHFRN 591_ DIIFS 596_ KAGDE 601_ SNIIA 606_ SRLYL 611_ VARTS 616_ RDKQK 621_ EITEV 626_ LEKLR 631_ PLSLS 636_ KSIRF 641_ IVFNP 646_ SFVFM 651_ DHYSL 656_ SVTVP 661_ VLIAG 666_ FGVLL 671_ VLILT 676_ FFLVI 681_ HPLGN 686_ FWLIL 691_ SVTSI 696_ ELGVL 701_ GLMTL 706_ WNVDM 711_ DCISI 716_ LCLIY 721_ TLNFA 726_ IDHCA 731_ PLLFT 736_ FVLAT 741_ EHTRT 746_ QCIKS 751_ SLQDH 756_ GTAIL 761_ QNVTS 766_ FLIGL 771_ VPLLF 776_ VPSNL 781_ TFTLF 786_ KCLLL 791_ TGGCT 796_ LLHCF 801_ VILPV 806_ FLTFF 811_ PPSKK 816_ HHKKK 821_ KRAKR 826_ KEREE 831_ IECIE 836_ IQENP 841_DHVTT
1: Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells