Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)
1_MAGLW 6_ LGLVW 11_ QKLLL 16_ WGAAS 21_ ALSLA 26_ GASLV 31_ LSLLQ 36_ RVASY 41_ ARKWQ 46_ QMRPI 51_ PTVAR 56_ AYPLV 61_ GHALL 66_ MKPDG 71_ REFFQ 76_ QIIEY 81_ TEEYR 86_ HMPLL 91_ KLWVG 96_ PVPMV 101_ ALYNA 106_ ENVEV 111_ ILTSS 116_ KQIDK 121_ SSMYK 126_ FLEPW 131_ LGLGL 136_ LTSTG 141_ NKWRS 146_ RRKML 151_ TPTFH 156_ FTILE 161_ DFLDI 166_ MNEQA 171_ NILVK 176_ KLEKH 181_ INQEA 186_ FNCFF 191_ YITLC 196_ ALDII 201_ CETAM 206_ GKNIG 211_ AQSND 216_ DSEYV 221_ RAVYR 226_ MSEMI 231_ FRRIK 236_ MPWLW 241_ LDLWY 246_ LMFKE 251_ GWEHK 256_ KSLQI 261_ LHTFT 266_ NSVIA 271_ ERANE 276_ MNANE 281_ DCRGD 286_ GRGSA 291_ PSKNK 296_ RRAFL 301_ DLLLS 306_ VTDDE 311_ GNRLS 316_ HEDIR 321_ EEVDT 326_ FMFEG 331_ HDTTA 336_ AAINW 341_ SLYLL 346_ GSNPE 351_ VQKKV 356_ DHELD 361_ DVFGK 366_ SDRPA 371_ TVEDL 376_ KKLRY 381_ LECVI 386_ KETLR 391_ LFPSV 396_ PLFAR 401_ SVSED 406_ CEVAG 411_ YRVLK 416_ GTEAV 421_ IIPYA 426_ LHRDP 431_ RYFPN 436_ PEEFQ 441_ PERFF 446_ PENAQ 451_ GRHPY 456_ AYVPF 461_ SAGPR 466_ NCIGQ 471_ KFAVM 476_ EEKTI 481_ LSCIL 486_ RHFWI 491_ ESNQK 496_ REELG 501_ LEGQL 506_ ILRPS 511_ NGIWI 516_KLKRR
1: A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs (PubMed:22772592). Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16) (PubMed:19661213). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)