Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane and TPR repeat-containing protein 3)
1_MANIN 6_ LKEIT 11_ LIVGV 16_ VTACY 21_ WNSLF 26_ CGFVF 31_ DDVSA 36_ ILDNK 41_ DLHPS 46_ TPLKT 51_ LFQND 56_ FWGTP 61_ MSEER 66_ SHKSY 71_ RPLTV 76_ LTFRL 81_ NYLLS 86_ ELKPM 91_ SYHLL 96_ NMIFH 101_ AVVSV 106_ IFLKV 111_ CKLFL 116_ DNKSS 121_ VIASL 126_ LFAVH 131_ PIHTE 136_ AVTGV 141_ VGRAE 146_ LLSSI 151_ FFLAA 156_ FLSYT 161_ RSKGP 166_ DNSII 171_ WTPIA 176_ LTVFL 181_ VAVAT 186_ LCKEQ 191_ GITVV 196_ GICCV 201_ YEVFI 206_ AQGYT 211_ LPLLC 216_ TTAGQ 221_ FLRGK 226_ GSIPF 231_ SMLQT 236_ LVKLI 241_ VLMFS 246_ TLLLV 251_ VIRVQ 256_ VIQSQ 261_ LPVFT 266_ RFDNP 271_ AAVSP 276_ TPTRQ 281_ LTFNY 286_ LLPVN 291_ AWLLL 296_ NPSEL 301_ CCDWT 306_ MGTIP 311_ LIESL 316_ LDIRN 321_ LATFT 326_ FFCFL 331_ GMLGV 336_ FSIRY 341_ SGDSS 346_ KTVLM 351_ ALCLM 356_ ALPFI 361_ PASNL 366_ FFPVG 371_ FVVAE 376_ RVLYV 381_ PSMGF 386_ CILVA 391_ HGWQK 396_ ISTKS 401_ VFKKL 406_ SWICL 411_ SMVIL 416_ THSLK 421_ TFHRN 426_ WDWES 431_ EYTLF 436_ MSALK 441_ VNKNN 446_ AKLWN 451_ NVGHA 456_ LENEK 461_ NFERA 466_ LKYFL 471_ QATHV 476_ QPDDI 481_ GAHMN 486_ VGRTY 491_ KNLNR 496_ TKEAE 501_ ESYMM 506_ AKSLM 511_ PQIIP 516_ GKKYA 521_ ARIAP 526_ NHLNV 531_ YINLA 536_ NLIRA 541_ NESRL 546_ EEADQ 551_ LYRQA 556_ ISMRP 561_ DFKQA 566_ YISRG 571_ ELLLK 576_ MNKPL 581_ KAKEA 586_ YLKAL 591_ ELDRN 596_ NADLW 601_ YNLAI 606_ VHIEL 611_ KEPNE 616_ ALKKN 621_ FNRAL 626_ ELNPK 631_ HKLAL 636_ FNSAI 641_ VMQES 646_ GEVKL 651_ RPEAR 656_ KRLLS 661_ YINEE 666_ PLDAN 671_ GYFNL 676_ GMLAM 681_ DDKKD 686_ NEAEI 691_ WMKKA 696_ IKLQA 701_ DFRSA 706_ LFNLA 711_ LLYSQ 716_ TAKEL 721_ KALPI 726_ LEELL 731_ RYYPD 736_ HIKGL 741_ ILKGD 746_ ILMNQ 751_ KKDIL 756_ GAKKC 761_ FERIL 766_ EMDPS 771_ NVQGK 776_ HNLCV 781_ VYFEE 786_ KDLLK 791_ AERCL 796_ LETLA 801_ LAPHE 806_ EYIQR 811_ HLNIV 816_ RDKIS 821_ SSSFI 826_ EPIFP 831_ TSKIS 836_ SVEGK 841_ KIPTE 846_ SVKEI 851_ RGESR 856_ QTQIV 861_ KTSDN 866_ KSQSK 871_ SNKQL 876_ GKNGD 881_ EETPH 886_ KTTKD 891_ IKEIE 896_ KKRVA 901_ ALKRL 906_EEIER
1: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response