Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)
1_MLSSR 6_ AEAAM 11_ TAADR 16_ AIQRF 21_ LRTGA 26_ AVRYK 31_ VMKNW 36_ GVIGG 41_ IAAAL 46_ AAGIY 51_ VIWGP 56_ ITERK 61_ KRRKG 66_ LVPGL 71_ VNLGN 76_ TCFMN 81_ SLLQG 86_ LSACP 91_ AFIRW 96_ LEEFT 101_ SQYSR 106_ DQKEP 111_ PSHQY 116_ LSLTL 121_ LHLLK 126_ ALSCQ 131_ EVTDD 136_ EVLDA 141_ SCLLD 146_ VLRMY 151_ RWQIS 156_ SFEEQ 161_ DAHEL 166_ FHVIT 171_ SSLED 176_ ERDRQ 181_ PRVTH 186_ LFDVH 191_ SLEQQ 196_ SEITP 201_ KQITC 206_ RTRGS 211_ PHPTS 216_ NHWKS 221_ QHPFH 226_ GRLTS 231_ NMVCK 236_ HCEHQ 241_ SPVRF 246_ DTFDS 251_ LSLSI 256_ PAATW 261_ GHPLT 266_ LDHCL 271_ HHFIS 276_ SESVR 281_ DVVCD 286_ NCTKI 291_ EAKGT 296_ LNGEK 301_ VEHQR 306_ TTFVK 311_ QLKLG 316_ KLPQC 321_ LCIHL 326_ QRLSW 331_ SSHGT 336_ PLKRH 341_ EHVQF 346_ NEFLM 351_ MDIYK 356_ YHLLG 361_ HKPSQ 366_ HNPKL 371_ NKNPG 376_ PTLEL 381_ QDGPG 386_ APTPV 391_ LNQPG 396_ APKTQ 401_ IFMNG 406_ ACSPS 411_ LLPTL 416_ SAPMP 421_ FPLPV 426_ VPDYS 431_ SSTYL 436_ FRLMA 441_ VVVHH 446_ GDMHS 451_ GHFVT 456_ YRRSP 461_ PSARN 466_ PLSTS 471_ NQWLW 476_ VSDDT 481_ VRKAS 486_ LQEVL 491_ SSSAY 496_ LLFYE 501_ RVLSR 506_ MQHQS 511_QECKS
1: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity)