Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin-specific peptidase 53)
1_MAWVK 6_ FLRKP 11_ GGNLG 16_ KVYQP 21_ GSMLS 26_ LAPTK 31_ GLLNE 36_ PGQNS 41_ CFLNS 46_ AVQVL 51_ WQLDI 56_ FRRSL 61_ RVLTG 66_ HVCQG 71_ DACIF 76_ CALKT 81_ IFAQF 86_ QHSRE 91_ KALPS 96_ DNIRH 101_ ALAES 106_ FKDEQ 111_ RFQLG 116_ LMDDA 121_ AECFE 126_ NMLER 131_ IHFHI 136_ VPSRD 141_ ADMCT 146_ SKSCI 151_ THQKF 156_ AMTLY 161_ EQCVC 166_ RSCGA 171_ SSDPL 176_ PFTEF 181_ VRYIS 186_ TTALC 191_ NEVER 196_ MLERH 201_ ERFKP 206_ EMFAE 211_ LLQAA 216_ NTTDD 221_ YRKCP 226_ SNCGQ 231_ KIKIR 236_ RVLMN 241_ CPEIV 246_ TIGLV 251_ WDSEH 256_ SDLTE 261_ AVVRN 266_ LATHL 271_ YLPGL 276_ FYRVT 281_ DENAK 286_ NSELN 291_ LVGMI 296_ CYTSQ 301_ HYCAF 306_ AFHTK 311_ SSKWV 316_ FFDDA 321_ NVKEI 326_ GTRWK 331_ DVVSK 336_ CIRCH 341_ FQPLL 346_ LFYAN 351_ PDGTA 356_ VSTED 361_ ALRQV 366_ ISWSH 371_ YKSVA 376_ ENMGC 381_ EKPVI 386_ HKSDN 391_ LKENG 396_ FGDQA 401_ KQREN 406_ QKFPT 411_ DNISS 416_ SNRSH 421_ SHTGV 426_ GKGPA 431_ KLSHI 436_ DQREK 441_ IKDIS 446_ RECAL 451_ KAIEQ 456_ KNLLS 461_ SQRKD 466_ LEKGQ 471_ RKDLG 476_ RHRDL 481_ VDEDL 486_ SHFQS 491_ GSPPA 496_ PNGFK 501_ QHGNP 506_ HLYHS 511_ QGKGS 516_ YKHDR 521_ VVPQS 526_ RASAQ 531_ IISSS 536_ KSQIL 541_ APGEK 546_ ITGKV 551_ KSDNG 556_ TGYDT 561_ DSSQD 566_ SRDRG 571_ NSCDS 576_ SSKSR 581_ NRGWK 586_ PMRET 591_ LNVDS 596_ IFSES 601_ EKRQH 606_ SPRHK 611_ PNISN 616_ KPKSS 621_ KDPSF 626_ SNWPK 631_ ENPKQ 636_ KGLMT 641_ IYEDE 646_ MKQEI 651_ GSRSS 656_ LESNG 661_ KGAEK 666_ NKGLV 671_ EGKVH 676_ GDNWQ 681_ MQRTE 686_ SGYES 691_ SDHIS 696_ NGSTN 701_ LDSPV 706_ IDGNG 711_ TVMDI 716_ SGVKE 721_ TVCFS 726_ DQITT 731_ SNLNK 736_ ERGDC 741_ TSLQS 746_ QHHLE 751_ GFRKE 756_ LRNLE 761_ AGYKS 766_ HEFHP 771_ ESHLQ 776_ IKNHL 781_ IKRSH 786_ VHEDN 791_ GKLFP 796_ SSSLQ 801_ IPKDH 806_ NAREH 811_ IHQSD 816_ EQKLE 821_ KPNEC 826_ KFSEW 831_ LNIEN 836_ SERTG 841_ LPFHV 846_ DNSAS 851_ GKRVN 856_ SNEPS 861_ SLWSS 866_ HLRTV 871_ GLKPE 876_ TAPLI 881_ QQQNI 886_ MDQCY 891_ FENSL 896_ STECI 901_ IRSAS 906_ RSDGC 911_ QMPKL 916_ FCQNL 921_ PPPLP 926_ PKKYA 931_ ITSVP 936_ QSEKS 941_ ESTPD 946_ VKLTE 951_ VFKAT 956_ SHLPK 961_ HSLST 966_ ASEPS 971_ LEVST 976_ HMNDE 981_ RHKET 986_ FQVRE 991_ CFGNT 996_ PNCPS 1001_ SSSTN 1006_ DFQAN 1011_ SGAID 1016_ AFCQP 1021_ ELDSI 1026_ STCPN 1031_ ETVSL 1036_ TTYFS 1041_ VDSCM 1046_ TDTYR 1051_ LKYHQ 1056_ RPKLS 1061_ FPESS 1066_GFCNN
1: Deubiquitinase that mediates 'Lys-63'-linked deubiquitination of tight junction proteins, such as MARVELD2 and LSR, and which is involved in the survival of auditory hair cells and hearing (PubMed:32124521, PubMed:39587316). Specifically cleaves 'Lys-63'-linked polyubiquitin chains composed of at least 3 ubiquitin molecules, while it is not able to deubiquitinate substrates with shorter ubiquitin chains: recognizes ubiquitin chain in position S2 and catalyzes en bloc cleavage of polyubiquitin chains from substrate proteins (PubMed:39587316). Probably acts by modulating the barrier properties and mechanical stability of tight junctions via deubiquitination of MARVELD2 and LSR (PubMed:32124521, PubMed:39587316)