Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51)
1_MAQVR 6_ ETSLP 11_ SGSGV 16_ RWISG 21_ GGGGA 26_ SPEEA 31_ VEKAG 36_ KMEEA 41_ AAGAT 46_ KASSR 51_ REAEE 56_ MKLEP 61_ LQERE 66_ PAPEE 71_ NLTWS 76_ SSGGD 81_ EKVLP 86_ SIPLR 91_ CHSSS 96_ SPVCP 101_ RRKPR 106_ PRPQP 111_ RARSR 116_ SQPGL 121_ SAPPP 126_ PPARP 131_ PPPPP 136_ PPPPP 141_ APRPR 146_ AWRGS 151_ RRRSR 156_ PGSRP 161_ QTRRS 166_ CSGDL 171_ DGSGD 176_ PGGLG 181_ DWLLE 186_ VEFGQ 191_ GPTGC 196_ SHVES 201_ FKVGK 206_ NWQKN 211_ LRLIY 216_ QRFVW 221_ SGTPE 226_ TRKRK 231_ AKSCI 236_ CHVCS 241_ THMNR 246_ LHSCL 251_ SCVFF 256_ GCFTE 261_ KHIHK 266_ HAETK 271_ QHHLA 276_ VDLYH 281_ GVIYC 286_ FMCKD 291_ YVYDK 296_ DIEQI 301_ AKETK 306_ EKILR 311_ LLTST 316_ STDVS 321_ HQQFM 326_ TSGFE 331_ DKQST 336_ CETKE 341_ QEPKL 346_ VKPKK 351_ KRRKK 356_ SVYTV 361_ GLRGL 366_ INLGN 371_ TCFMN 376_ CIVQA 381_ LTHIP 386_ LLKDF 391_ FLSDK 396_ HKCIM 401_ TSPSL 406_ CLVCE 411_ MSSLF 416_ HAMYS 421_ GSRTP 426_ HIPYK 431_ LLHLI 436_ WIHAE 441_ HLAGY 446_ RQQDA 451_ HEFLI 456_ AILDV 461_ LHRHS 466_ KDDSG 471_ GQEAN 476_ NPNCC 481_ NCIID 486_ QIFTG 491_ GLQSD 496_ VTCQA 501_ CHSVS 506_ TTIDP 511_ CWDIS 516_ LDLPG 521_ SCATF 526_ DSQNP 531_ ERADS 536_ TVSRD 541_ DHIPG 546_ IPSLT 551_ DCLQW 556_ FTRPE 561_ HLGSS 566_ AKIKC 571_ NSCQS 576_ YQEST 581_ KQLTM 586_ KKLPI 591_ VACFH 596_ LKRFE 601_ HVGKQ 606_ RRKIN 611_ TFISF 616_ PLELD 621_ MTPFL 626_ ASTKE 631_ SRMKE 636_ GQPPT 641_ DCVPN 646_ ENKYS 651_ LFAVI 656_ NHHGT 661_ LESGH 666_ YTSFI 671_ RQQKD 676_ QWFSC 681_ DDAII 686_ TKATI 691_ EDLLY 696_ SEGYL 701_ LFYHK 706_QGLEK
1: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998, PubMed:33022275). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1 (PubMed:34188037). In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1 (PubMed:29119051)