Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)
1_MSWKR 6_ NYFSG 11_ GRGSV 16_ QGMFA 21_ PRSST 26_ SIAPS 31_ KGLSN 36_ EPGQN 41_ SCFLN 46_ SALQV 51_ LWHLD 56_ IFRRS 61_ FRQLT 66_ THKCM 71_ GDSCI 76_ FCALK 81_ GIFNQ 86_ FQCSS 91_ EKVLP 96_ SDTLR 101_ SALAK 106_ TFQDE 111_ QRFQL 116_ GIMDD 121_ AAECF 126_ ENLLM 131_ RIHFH 136_ IADET 141_ KEDIC 146_ TAQHC 151_ ISHQK 156_ FAMTL 161_ FEQCV 166_ CTSCG 171_ ATSDP 176_ LPFIQ 181_ MVHYI 186_ STTSL 191_ CNQAI 196_ CMLER 201_ REKPS 206_ PSMFG 211_ ELLQN 216_ ASTMG 221_ DLRNC 226_ PSNCG 231_ ERIRI 236_ RRVLM 241_ NAPQI 246_ ITIGL 251_ VWDSD 256_ HSDLA 261_ EDVIH 266_ SLGTC 271_ LKLGD 276_ LFFRV 281_ TDDRA 286_ KQSEL 291_ YLVGM 296_ ICYYG 301_ KHYST 306_ FFFQT 311_ KIRKW 316_ MYFDD 321_ AHVKE 326_ IGPKW 331_ KDVVT 336_ KCIKG 341_ HYQPL 346_ LLLYA 351_ DPQGT 356_ PVSTQ 361_ DLPPQ 366_ AEFQS 371_ YSRTC 376_ YDSED 381_ SGREP 386_ SISSD 391_ TRTDS 396_ STESY 401_ PYKHS 406_ HHESV 411_ VSHFS 416_ SDSQG 421_ TVIYN 426_ VENDS 431_ MSQSS 436_ RDTGH 441_ LTDSE 446_ CNQKH 451_ TSKKG 456_ SLIER 461_ KRSSG 466_ RVRRK 471_ GDEPQ 476_ ASGYH 481_ SEGET 486_ LKEKQ 491_ APRNA 496_ SKPSS 501_ STNRL 506_ RDFKE 511_ TVSNM 516_ IHNRP 521_ SLASQ 526_ TNVGS 531_ HCRGR 536_ GGDQP 541_ DKKPP 546_ RTLPL 551_ HSRDW 556_ EIEST 561_ SSESK 566_ SSSSS 571_ KYRPT 576_ WRPKR 581_ ESLNI 586_ DSIFS 591_ KDKRK 596_ HCGYT 601_ QLSPF 606_ SEDSA 611_ KEFIP 616_ DEPSK 621_ PPSYD 626_ IKFGG 631_ PSPQY 636_ KRWGP 641_ ARPGS 646_ HLLEQ 651_ HPRLI 656_ QRMES 661_ GYESS 666_ ERNSS 671_ SPVSL 676_ DAALP 681_ ESSNV 686_ YRDPS 691_ AKRSA 696_ GLVPS 701_ WRHIP 706_ KSHSS 711_ SILEV 716_ DSTAS 721_ MGGWT 726_ KSQPF 731_ SGEEI 736_ SSKSE 741_ LDELQ 746_ EEVAR 751_ RAQEQ 756_ ELRRK 761_ REKEL 766_ EAAKG 771_ FNPHP 776_ SRFMD 781_ LDELQ 786_ NQGRS 791_ DGFER 796_ SLQEA 801_ ESVFE 806_ ESLHL 811_ EQKGD 816_ CAAAL 821_ ALCNE 826_ AISKL 831_ RLALH 836_ GASCS 841_ THSRA 846_ LVDKK 851_ LQISI 856_ RKARS 861_ LQDRM 866_ QQQQS 871_ PQQPS 876_ QPSAC 881_ LPTQA 886_ GTLSQ 891_ PTSEQ 896_ PIPLQ 901_ VLLSQ 906_ EAQLE 911_ SGMDT 916_ EFGAS 921_ SFFHS 926_ PASCH 931_ ESHSS 936_ LSPES 941_ SAPQH 946_ SSPSR 951_ SALKL 956_ LTSVE 961_ VDNIE 966_ PSAFH 971_ RQGLP 976_ KAPGW 981_ TEKNS 986_ HHSWE 991_ PLDAP 996_ EGKLQ 1001_ GSRCD 1006_ NSSCS 1011_ KLPPQ 1016_ EGRGI 1021_ AQEQL 1026_ FQEKK 1031_ DPANP 1036_ SPVMP 1041_ GIATS 1046_ ERGDE 1051_ HSLGC 1056_ SPSNS 1061_ SAQPS 1066_ LPLYR 1071_ TCHPI 1076_ MPVAS 1081_ SFVLH 1086_ CPDPV 1091_ QKTNQ 1096_ CLQGQ 1101_ SLKTS 1106_ LTLKV 1111_ DRGSE 1116_ ETYRP 1121_ EFPST 1126_ KGLVR 1131_ SLAEQ 1136_ FQRMQ 1141_ GVSMR 1146_ DSTGF 1151_ KDRSL 1156_ SGSLR 1161_ KNSSP 1166_ SDSKP 1171_ PFSQG 1176_ QEKGH 1181_ WPWAK 1186_ QQSSL 1191_ EGGDR 1196_ PLSWE 1201_ ESTEH 1206_ SSLAL 1211_ NSGLP 1216_ NGETS 1221_ SGGQP 1226_ RLAEP 1231_ DIYQE 1236_ KLSQV 1241_ RDVRS 1246_ KDLGS 1251_ STDLG 1256_ TSLPL 1261_ DSWVN 1266_ ITRFC 1271_ DSQLK 1276_ HGAPR 1281_ PGMKS 1286_ SPHDS 1291_ HTCVT 1296_ YPERN 1301_ HILLH 1306_ PHWNQ 1311_ DTEQE 1316_ TSELE 1321_ SLYQA 1326_ SLQAS 1331_ QAGCS 1336_ GWGQQ 1341_ DTAWH 1346_ PLSQT 1351_ GSADG 1356_ MGRRL 1361_ HSAHD 1366_ PGLSK 1371_ TSTAE 1376_ MEHGL 1381_ HEART 1386_ VRTSQ 1391_ ATPCR 1396_ GLSRE 1401_ CGEDE 1406_ QYSAE 1411_ NLRRI 1416_ SRSLS 1421_ GTVVS 1426_ EREEA 1431_ PVSSH 1436_ SFDSS 1441_ NVRKP 1446_ LETGH 1451_ RCSSS 1456_ SSLPV 1461_ IHDPS 1466_ VFLLG 1471_ PQLYL 1476_ PQPQF 1481_ LSPDV 1486_ LMPTM 1491_ AGEPN 1496_ RLPGT 1501_ SRSVQ 1506_ QFLAM 1511_ CDRGE 1516_ TSQGA 1521_ KYTGR 1526_ TLNYQ 1531_ SLPHR 1536_ SRTDN 1541_ SWAPW 1546_ SETNQ 1551_ HIGTR 1556_ FLTTP 1561_ GCNPQ 1566_ LTYTA 1571_ TLPER 1576_ SKGLQ 1581_ VPHTQ 1586_ SWSDL 1591_ FHSPS 1596_ HPPIV 1601_ HPVYP 1606_ PSSSL 1611_ HVPLR 1616_ SAWNS 1621_ DPVPG 1626_ SRTPG 1631_ PRRVD 1636_ MPPDD 1641_ DWRQS 1646_ SYASH 1651_ SGHRR 1656_ TVGEG 1661_ FLFVL 1666_ SDAPR 1671_ REQIR 1676_ARVLQ
1: Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171)