Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin-specific peptidase 50)
1_MTSQP 6_ SLPAD 11_ DFDIY 16_ HVLAE 21_ CTDYY 26_ DTLPV 31_ KEADG 36_ NQPHF 41_ QGVTG 46_ LWNLG 51_ NTCCV 56_ NAISQ 61_ CLCSI 66_ LPLVE 71_ YFLTG 76_ KYITA 81_ LQKFL 86_ LPSDC 91_ SEVAT 96_ AFAYL 101_ MTDMW 106_ LGDSD 111_ CVSPE 116_ IFWSA 121_ LGNLY 126_ PAFTK 131_ KMQQD 136_ AQEFL 141_ ICVLN 146_ ELHEA 151_ LKKYH 156_ YSRRR 161_ SYEKG 166_ STQRC 171_ CRKWI 176_ TTETS 181_ IITQL 186_ FEEQL 191_ NYSIV 196_ CLKCE 201_ KCTYK 206_ NEVFT 211_ VFSLP 216_ IPSKY 221_ ECSLR 226_ DCLQC 231_ FFQQD 236_ ALTWN 241_ NEIHC 246_ SFCET 251_ KQETA 256_ VRASI 261_ SKAPK 266_ IIIFH 271_ LKRFD 276_ IQGTT 281_ KRKLR 286_ TDIHY 291_ PLTNL 296_ DLTPY 301_ ICSIF 306_ RKYPK 311_ YNLCA 316_ VVNHF 321_ GDLDG 326_ GHYTA 331_FCKNS
1: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein (PubMed:28094437). Regulates the ubiquitination and stability of the ACE2 protein (PubMed:36876523). Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint (PubMed:20930503)