Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2]
1_MEVLE 6_ SGEQG 11_ VLQWD 16_ RKLSE 21_ LSEPG 26_ DGEAL 31_ MYHTH 36_ FSELL 41_ DEFSQ 46_ NVLGQ 51_ LLNDP 56_ FLSEK 61_ SVSME 66_ VEPSP 71_ TSPAP 76_ LIQAE 81_ HSYSL 86_ CEEPR 91_ AQSPF 96_ THITT 101_ SDSFN 106_ DDEVE 111_ SEKWY 116_ LSTDF 121_ PSTSI 126_ KTEPV 131_ TDEPP 136_ PGLVP 141_ SVTLT 146_ ITAIS 151_ TPLEK 156_ EEPPL 161_ EMNTG 166_ VDSSC 171_ QTIIP 176_ KIKLE 181_ PHEVD 186_ QFLNF 191_ SPKEA 196_ PVDHL 201_ HLPPT 206_ PPSSH 211_ GSDSE 216_ GSLSP 221_ NPRLH 226_ PFSLP 231_ QTHSP 236_ SRAAP 241_ RAPSA 246_ LSSSP 251_ LLTAP 256_ HKLQG 261_ SGPLV 266_ LTEEE 271_ KRTLI 276_ AEGYP 281_ IPTKL 286_ PLSKS 291_ EEKAL 296_ KKIRR 301_ KIKNK 306_ ISAQE 311_ SRRKK 316_ KEYMD 321_ SLEKK 326_ VESCS 331_ TENLE 336_ LRKKV 341_ EVLEN 346_ TNRTL 351_ LQQLQ 356_ KLQTL 361_ VMGKV 366_ SRTCK 371_ LAGTQ 376_ TGTCL 381_ MVVVL 386_ CFAVA 391_ FGSFF 396_ QGYGP 401_ YPSAT 406_ KMALP 411_ SQHSL 416_ QEPYT 421_ ASVVR 426_ SRNLL 431_ IYEEH 436_ SPPEE 441_ SSSPG 446_ SAGEL 451_ GGWDR 456_ GSSLL 461_ RVSGL 466_ ESRPD 471_ VDLPH 476_ FIISN 481_ ETSLE 486_ KSVLL 491_ ELQQH 496_ LVSAK 501_ LEGNE 506_ TLKVV 511_ELDRR
1: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827)