Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48)
1_MQQKA 6_ FEESR 11_ YPWQE 16_ SFENV 21_ AVCLP 26_ LRCPR 31_ CGDHT 36_ RFRSL 41_ SSLRA 46_ HLEFS 51_ HSYEE 56_ RTLLT 61_ KCSLF 66_ PSLKD 71_ TDLVT 76_ SSELL 81_ KPGKL 86_ QSSGN 91_ VVKQK 96_ PSYVN 101_ LYSIS 106_ HEHSK 111_ DRKPF 116_ EVVAE 121_ RPVSY 126_ VQTYT 131_ AMDLH 136_ ADSLD 141_ GTRSG 146_ PGLPT 151_ SDTKA 156_ SFEAH 161_ VREKF 166_ NRMVE 171_ AVDRT 176_ IEKRI 181_ DKLTK 186_ ELAQK 191_ TAELL 196_ EVRAA 201_ FVQLT 206_ QKKQE 211_ VQRRE 216_ RALNR 221_ QVDVA 226_ VEMIA 231_ VLRQR 236_ LTESE 241_ EELLR 246_ KEEEV 251_ VTFNH 256_ FLEAA 261_ AEKEV 266_ QGKAR 271_ LQDFI 276_ ENLLQ 281_ RVELA 286_ EKQLE 291_ YYQSQ 296_ QASGF 301_ VRDLS 306_ GHVLT 311_ DISSN 316_ RKPKC 321_ LSRGH 326_ PHSVC 331_ NHPDL 336_ KAHFH 341_ PKGRN 346_ HLKKA 351_ KDDRA 356_ SMQPA 361_ KAIHE 366_ QAESS 371_ RDLCR 376_ PPKKG 381_ ELLGF 386_ GRKGN 391_ IRPKM 396_ AKKKP 401_TAIVN
1: Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040)