Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)
1_MSEDS 6_ RGDSR 11_ AESAK 16_ DLEKQ 21_ LRLRV 26_ CVLSE 31_ LQKTE 36_ RDYVG 41_ TLEFL 46_ VSAFL 51_ HRMNQ 56_ CAASK 61_ VDKNV 66_ TEETV 71_ KMLFS 76_ NIEDI 81_ LAVHK 86_ EFLKV 91_ VEECL 96_ HPEPN 101_ AQQEV 106_ GTCFL 111_ HFKDK 116_ FRIYD 121_ EYCSN 126_ HEKAQ 131_ KLLLE 136_ LNKIR 141_ TIRTF 146_ LLNCM 151_ LLGGR 156_ KNTDV 161_ PLEGY 166_ LVTPI 171_ QRICK 176_ YPLIL 181_ KELLK 186_ RTPRK 191_ HSDYA 196_ AVMEA 201_ LQAMK 206_ AVCSN 211_ INEAK 216_ RQMEK 221_ LEVLE 226_ EWQSH 231_ IEGWE 236_ GSNIT 241_ DTCTE 246_ MLMCG 251_ VLLKI 256_ SSGNI 261_ QERVF 266_ FLFDN 271_ LLVYC 276_ KRKHR 281_ RLKNS 286_ KASTD 291_ GHRYL 296_ FRGRI 301_ NTEVM 306_ EVENV 311_ DDGTA 316_ DFHSS 321_ GHIVV 326_ NGWKI 331_ HNTAK 336_ NKWFV 341_ CMAKT 346_ PEEKH 351_ EWFEA 356_ ILKER 361_ ERRKG 366_ LKLGM 371_ EQDTW 376_ VMISE 381_ QGEKL 386_ YKMMC 391_ RQGNL 396_ IKDRK 401_ RKLTT 406_ FPKCF 411_ LGSEF 416_ VSWLL 421_ EIGEI 426_ HRPEE 431_ GVHLG 436_ QALLE 441_ NGIIH 446_ HVTDK 451_ HQFKP 456_ EQMLY 461_ RFRYD 466_ DGTFY 471_ PRNEM 476_ QDVIS 481_ KGVRL 486_ YCRLH 491_ SLFTP 496_ VIRDK 501_ DYHLR 506_ TYKSV 511_ VMANK 516_ LIDWL 521_ IAQGD 526_ CRTRE 531_ EAMIF 536_ GVGLC 541_ DNGFM 546_ HHVLE 551_ KSEFK 556_ DEPLL 561_ FRFFS 566_ DEEME 571_ GSNMK 576_ HRLMK 581_ HDLKV 586_ VENVI 591_ AKSLL 596_ IKSNE 601_ GSYGF 606_ GLEDK 611_ NKVPI 616_ IKLVE 621_ KGSNA 626_ EMAGM 631_ EVGKK 636_ IFAIN 641_ GDLVF 646_ MRPFN 651_ EVDCF 656_ LKSCL 661_ NSRKP 666_ LRVLV 671_ STKPR 676_ ETVKI 681_ PDSAD 686_ GLGFQ 691_ IRGFG 696_ PSVVH 701_ AVGRG 706_ TVAAA 711_ AGLHP 716_ GQCII 721_ KVNGI 726_ NVSKE 731_ THASV 736_ IAHVT 741_ ACRKY 746_ RRPTK 751_ QDSIQ 756_ WVYNS 761_ IESAQ 766_ EDLQK 771_ SHSKP 776_ PGDEA 781_ GDAFD 786_ CKVEE 791_ VIDKF 796_ NTMAI 801_ IDGKK 806_ EHVSL 811_ TVDNV 816_ HLEYG 821_ VVYEY 826_ DSTAG 831_ IKCNV 836_ VEKMI 841_ EPKGF 846_ FSLTA 851_ KILEA 856_ LAKSD 861_ EHFVQ 866_ NCTSL 871_ NSLNE 876_ VIPTD 881_ LQSKF 886_ SALCS 891_ ERIEH 896_ LCQRI 901_ SSYKK 906_ FSRVL 911_ KNRAW 916_ PTFKQ 921_ AKSKI 926_ SPLHS 931_ SDFCP 936_ TNCHV 941_ NVMEV 946_ SYPKT 951_ STSLG 956_ SAFGV 961_ QLDSR 966_ KHNSH 971_ DKENK 976_ SSEQG 981_ KLSPM 986_ VYIQH 991_ TITTM 996_ AAPSG 1001_ LSLGQ 1006_ QDGHG 1011_ LRYLL 1016_ KEEDL 1021_ ETQDI 1026_ YQKLL 1031_ GKLQT 1036_ ALKEV 1041_ EMCVC 1046_ QIDDL 1051_ LSSIT 1056_ YSPKL 1061_ ERKTS 1066_ EGIIP 1071_ TDSDN 1076_ EKGER 1081_ NSKRV 1086_ CFNVA 1091_ GDEQE 1096_ DSGHD 1101_ TISNR 1106_ DSYSD 1111_ CNSNR 1116_ NSIAS 1121_ FTSIC 1126_ SSQCS 1131_ SYFHS 1136_ DEMDS 1141_ GDELP 1146_ LSVRI 1151_ SHDKQ 1156_ DKIHS 1161_ CLEHL 1166_ FSQVD 1171_ SITNL 1176_ LKGQA 1181_ VVRAF 1186_ DQTKY 1191_ LTPGR 1196_ GLQEF 1201_ QQEME 1206_ PKLSC 1211_ PKRLR 1216_ LHIKQ 1221_ DPWNL 1226_ PSSVR 1231_ TLAQN 1236_ IRKFV 1241_ EEVKC 1246_ RLLLA 1251_ LLEYS 1256_ DSETQ 1261_ LRRDM 1266_ VFCQT 1271_ LVATV 1276_ CAFSE 1281_ QLMAA 1286_ LNQMF 1291_ DNSKE 1296_ NEMET 1301_ WEASR 1306_ RWLDQ 1311_ IANAG 1316_ VLFHF 1321_ QSLLS 1326_ PNLTD 1331_ EQAML 1336_ EDTLV 1341_ ALFDL 1346_ EKVSF 1351_ YFKPS 1356_ EEEPL 1361_ VANVP 1366_ LTYQA 1371_ EGSRQ 1376_ ALKVY 1381_ FYIDS 1386_ YHFEQ 1391_ LPQRL 1396_ KNGGG 1401_ FKIHP 1406_ VLFAQ 1411_ ALESM 1416_ EGYYY 1421_ RDNVS 1426_ VEEFQ 1431_ AQINA 1436_ ASLEK 1441_ VKQYN 1446_ QKLRA 1451_ FYLDK 1456_ SNSPP 1461_ NSTSK 1466_ AAYVD 1471_ KLMRP 1476_ LNALD 1481_ ELYRL 1486_ VASFI 1491_ RSKRT 1496_ AACAN 1501_ TACSA 1506_ SGVGL 1511_ LSVSS 1516_ ELCNR 1521_ LGACH 1526_ IIMCS 1531_ SGVHR 1536_ CTLSV 1541_ TLEQA 1546_ IILAR 1551_ SHGLP 1556_ PRYIM 1561_ QATDV 1566_ MRKQG 1571_ ARVQN 1576_ TAKNL 1581_ GVRDR 1586_ TPQSA 1591_ PRLYK 1596_ LCEPP 1601_PPAGE
1: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase