Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)
1_MAQQQ 6_ MTSSQ 11_ KALML 16_ ELKSL 21_ QEEPV 26_ EGFRI 31_ TLVDE 36_ SDLYN 41_ WEVAI 46_ FGPPN 51_ TLYEG 56_ GYFKA 61_ HIKFP 66_ IDYPY 71_ SPPTF 76_ RFLTK 81_ MWHPN 86_ IYENG 91_ DVCIS 96_ ILHPP 101_ VDDPQ 106_ SGELP 111_ SERWN 116_ PTQNV 121_ RTILL 126_ SVISL 131_ LNEPN 136_ TFSPA 141_ NVDAS 146_ VMFRK 151_ WRDSK 156_ GKDKE 161_ YAEII 166_ RKQVS 171_ ATKAE 176_ AEKDG 181_ VKVPT 186_ TLAEY 191_ CIKTK 196_ VPSND 201_ NSSDL 206_ LYDDL 211_ YDDDI 216_ DDEDE 221_ EEEDA 226_ DCYDD 231_DDSGN
1: E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:12037680, PubMed:20061386, PubMed:38326650). In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination (PubMed:12037680, PubMed:20061386, PubMed:38326650). Works in collaboration with various Cul1-RING and Cul2-RING E3 ligase complexes (PubMed:38326650). May be involved in degradation of katenin (PubMed:12037680)